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Do we need to adjust for interim analyses in a Bayesian adaptive trial design?
BACKGROUND: Bayesian adaptive methods are increasingly being used to design clinical trials and offer several advantages over traditional approaches. Decisions at analysis points are usually based on the posterior distribution of the treatment effect. However, there is some confusion as to whether c...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288484/ https://www.ncbi.nlm.nih.gov/pubmed/32522284 http://dx.doi.org/10.1186/s12874-020-01042-7 |