X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of...

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Autores principales: Gu, Xuefan, Shen, Chao, Li, Hua, Goldys, Ewa M., Deng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288491/
https://www.ncbi.nlm.nih.gov/pubmed/32522291
http://dx.doi.org/10.1186/s12951-020-00644-z
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author Gu, Xuefan
Shen, Chao
Li, Hua
Goldys, Ewa M.
Deng, Wei
author_facet Gu, Xuefan
Shen, Chao
Li, Hua
Goldys, Ewa M.
Deng, Wei
author_sort Gu, Xuefan
collection PubMed
description In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.
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spelling pubmed-72884912020-06-11 X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system Gu, Xuefan Shen, Chao Li, Hua Goldys, Ewa M. Deng, Wei J Nanobiotechnology Research In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis. BioMed Central 2020-06-10 /pmc/articles/PMC7288491/ /pubmed/32522291 http://dx.doi.org/10.1186/s12951-020-00644-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Gu, Xuefan
Shen, Chao
Li, Hua
Goldys, Ewa M.
Deng, Wei
X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title_full X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title_fullStr X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title_full_unstemmed X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title_short X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
title_sort x-ray induced photodynamic therapy (pdt) with a mitochondria-targeted liposome delivery system
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288491/
https://www.ncbi.nlm.nih.gov/pubmed/32522291
http://dx.doi.org/10.1186/s12951-020-00644-z
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