Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur

[Image: see text] Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction ach...

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Autores principales: Zhu, Xiaoming, Zhou, Fengru, Yang, Yuan, Deng, Guobo, Liang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288589/
https://www.ncbi.nlm.nih.gov/pubmed/32548500
http://dx.doi.org/10.1021/acsomega.0c01150
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author Zhu, Xiaoming
Zhou, Fengru
Yang, Yuan
Deng, Guobo
Liang, Yun
author_facet Zhu, Xiaoming
Zhou, Fengru
Yang, Yuan
Deng, Guobo
Liang, Yun
author_sort Zhu, Xiaoming
collection PubMed
description [Image: see text] Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction achieves double C–S and one C–N bond formations via cleavage of two C–N bonds and multiple C–H bonds. Furthermore, the mechanism research shows that DMSO acts as an oxidant in the cyclization reaction.
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spelling pubmed-72885892020-06-15 Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur Zhu, Xiaoming Zhou, Fengru Yang, Yuan Deng, Guobo Liang, Yun ACS Omega [Image: see text] Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction achieves double C–S and one C–N bond formations via cleavage of two C–N bonds and multiple C–H bonds. Furthermore, the mechanism research shows that DMSO acts as an oxidant in the cyclization reaction. American Chemical Society 2020-05-29 /pmc/articles/PMC7288589/ /pubmed/32548500 http://dx.doi.org/10.1021/acsomega.0c01150 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhu, Xiaoming
Zhou, Fengru
Yang, Yuan
Deng, Guobo
Liang, Yun
Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title_full Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title_fullStr Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title_full_unstemmed Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title_short Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur
title_sort catalyst- and additive-free method for the synthesis of 2-substituted benzothiazoles from aromatic amines, aliphatic amines, and elemental sulfur
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288589/
https://www.ncbi.nlm.nih.gov/pubmed/32548500
http://dx.doi.org/10.1021/acsomega.0c01150
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