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Muscle–Organ Crosstalk: The Emerging Roles of Myokines

Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an e...

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Autores principales: Severinsen, Mai Charlotte Krogh, Pedersen, Bente Klarlund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288608/
https://www.ncbi.nlm.nih.gov/pubmed/32393961
http://dx.doi.org/10.1210/endrev/bnaa016
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author Severinsen, Mai Charlotte Krogh
Pedersen, Bente Klarlund
author_facet Severinsen, Mai Charlotte Krogh
Pedersen, Bente Klarlund
author_sort Severinsen, Mai Charlotte Krogh
collection PubMed
description Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.
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spelling pubmed-72886082020-06-15 Muscle–Organ Crosstalk: The Emerging Roles of Myokines Severinsen, Mai Charlotte Krogh Pedersen, Bente Klarlund Endocr Rev Reviews Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases. Oxford University Press 2020-05-11 /pmc/articles/PMC7288608/ /pubmed/32393961 http://dx.doi.org/10.1210/endrev/bnaa016 Text en © Endocrine Society 2020. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Severinsen, Mai Charlotte Krogh
Pedersen, Bente Klarlund
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title_full Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title_fullStr Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title_full_unstemmed Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title_short Muscle–Organ Crosstalk: The Emerging Roles of Myokines
title_sort muscle–organ crosstalk: the emerging roles of myokines
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288608/
https://www.ncbi.nlm.nih.gov/pubmed/32393961
http://dx.doi.org/10.1210/endrev/bnaa016
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