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Pitfalls in Single Clone CRISPR-Cas9 Mutagenesis to Fine-Map Regulatory Intervals

The majority of genetic variants affecting complex traits map to regulatory regions of genes, and typically lie in credible intervals of 100 or more SNPs. Fine mapping of the causal variant(s) at a locus depends on assays that are able to discriminate the effects of polymorphisms or mutations on gen...

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Detalles Bibliográficos
Autores principales:	Tian, Ruoyu, Pan, Yidan, Etheridge, Thomas H. A., Deshmukh, Harshavardhan, Gulick, Dalia, Gibson, Greg, Bao, Gang, Lee, Ciaran M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288657/ https://www.ncbi.nlm.nih.gov/pubmed/32375333 http://dx.doi.org/10.3390/genes11050504

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