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Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction

Ischemic heart disease is a leading cause of mortality in the world. This study aimed to investigate the cardioprotective effects of germinated brown rice (GBR) on a rabbit model of chronic myocardial infarction. Eighteen New Zealand white rabbits were randomly divided into three groups receiving: 1...

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Autores principales: Petchdee, Soontaree, Laosripaiboon, Wanpen, Jarussophon, Nongpanga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288738/
https://www.ncbi.nlm.nih.gov/pubmed/32705062
http://dx.doi.org/10.1093/tas/txaa067
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author Petchdee, Soontaree
Laosripaiboon, Wanpen
Jarussophon, Nongpanga
author_facet Petchdee, Soontaree
Laosripaiboon, Wanpen
Jarussophon, Nongpanga
author_sort Petchdee, Soontaree
collection PubMed
description Ischemic heart disease is a leading cause of mortality in the world. This study aimed to investigate the cardioprotective effects of germinated brown rice (GBR) on a rabbit model of chronic myocardial infarction. Eighteen New Zealand white rabbits were randomly divided into three groups receiving: 1) regular rabbit food; 2) regular rabbit food plus vehicle; and 3) regular rabbit food plus GBR for 120 d. The left circumflex coronary artery was ligated to induce myocardial ischemia 60 d after starting the experiment (baseline). Heart functions were monitored by electrocardiography and echocardiography at 0, 30, and 60 d after coronary artery ligation. The incidences of heart rate (HR) and ventricular arrhythmias have been compared between groups. GBR showed the effects to prevent life-threatening ventricular tachycardia and electrocardiographic signs of myocardial ischemia in a model of arrhythmias. GBR consumption group exhibited significantly improved cardiac function and reduced the HR, along with reduced mean arterial pressure and plasma glucose level. The results demonstrated that GBR exerts cardioprotective effects against chronic myocardial injury in rabbits. These biological actions of GBR may explain the benefits gained from the use of GBR products as a possible prophylactic lifestyle intervention.
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spelling pubmed-72887382020-07-22 Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction Petchdee, Soontaree Laosripaiboon, Wanpen Jarussophon, Nongpanga Transl Anim Sci Animal Models Ischemic heart disease is a leading cause of mortality in the world. This study aimed to investigate the cardioprotective effects of germinated brown rice (GBR) on a rabbit model of chronic myocardial infarction. Eighteen New Zealand white rabbits were randomly divided into three groups receiving: 1) regular rabbit food; 2) regular rabbit food plus vehicle; and 3) regular rabbit food plus GBR for 120 d. The left circumflex coronary artery was ligated to induce myocardial ischemia 60 d after starting the experiment (baseline). Heart functions were monitored by electrocardiography and echocardiography at 0, 30, and 60 d after coronary artery ligation. The incidences of heart rate (HR) and ventricular arrhythmias have been compared between groups. GBR showed the effects to prevent life-threatening ventricular tachycardia and electrocardiographic signs of myocardial ischemia in a model of arrhythmias. GBR consumption group exhibited significantly improved cardiac function and reduced the HR, along with reduced mean arterial pressure and plasma glucose level. The results demonstrated that GBR exerts cardioprotective effects against chronic myocardial injury in rabbits. These biological actions of GBR may explain the benefits gained from the use of GBR products as a possible prophylactic lifestyle intervention. Oxford University Press 2020-05-20 /pmc/articles/PMC7288738/ /pubmed/32705062 http://dx.doi.org/10.1093/tas/txaa067 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society of Animal Science. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal Models
Petchdee, Soontaree
Laosripaiboon, Wanpen
Jarussophon, Nongpanga
Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title_full Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title_fullStr Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title_full_unstemmed Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title_short Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
title_sort cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction
topic Animal Models
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288738/
https://www.ncbi.nlm.nih.gov/pubmed/32705062
http://dx.doi.org/10.1093/tas/txaa067
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