Preventing SARS-CoV-2 infection by blocking a tissue serine protease

Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacologic...

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Detalles Bibliográficos
Autores principales: Jankousky, Katherine C., Schultz, Jonathan, Windham, Samuel, Henao-Martínez, Andrés F., Franco-Paredes, Carlos, Shapiro, Leland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288835/
https://www.ncbi.nlm.nih.gov/pubmed/32577236
http://dx.doi.org/10.1177/2049936120933076
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author Jankousky, Katherine C.
Schultz, Jonathan
Windham, Samuel
Henao-Martínez, Andrés F.
Franco-Paredes, Carlos
Shapiro, Leland
author_facet Jankousky, Katherine C.
Schultz, Jonathan
Windham, Samuel
Henao-Martínez, Andrés F.
Franco-Paredes, Carlos
Shapiro, Leland
author_sort Jankousky, Katherine C.
collection PubMed
description Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacological targets for the treatment of viral pathogens has traditionally relied in blockage of specific steps in their replicative lifecycle in human cells. However, an alternative approach is reducing the molecular cleavage of the viral surface spike protein of SARS-CoV-2 to prevent viral entry into epithelial cells.
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spelling pubmed-72888352020-06-22 Preventing SARS-CoV-2 infection by blocking a tissue serine protease Jankousky, Katherine C. Schultz, Jonathan Windham, Samuel Henao-Martínez, Andrés F. Franco-Paredes, Carlos Shapiro, Leland Ther Adv Infect Dis Commentary Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacological targets for the treatment of viral pathogens has traditionally relied in blockage of specific steps in their replicative lifecycle in human cells. However, an alternative approach is reducing the molecular cleavage of the viral surface spike protein of SARS-CoV-2 to prevent viral entry into epithelial cells. SAGE Publications 2020-06-10 /pmc/articles/PMC7288835/ /pubmed/32577236 http://dx.doi.org/10.1177/2049936120933076 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Jankousky, Katherine C.
Schultz, Jonathan
Windham, Samuel
Henao-Martínez, Andrés F.
Franco-Paredes, Carlos
Shapiro, Leland
Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title_full Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title_fullStr Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title_full_unstemmed Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title_short Preventing SARS-CoV-2 infection by blocking a tissue serine protease
title_sort preventing sars-cov-2 infection by blocking a tissue serine protease
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288835/
https://www.ncbi.nlm.nih.gov/pubmed/32577236
http://dx.doi.org/10.1177/2049936120933076
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