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Phage therapy: awakening a sleeping giant
For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, both properly and improperly, antibiotic-resista...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288995/ https://www.ncbi.nlm.nih.gov/pubmed/33525818 http://dx.doi.org/10.1042/ETLS20170002 |
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author | Roach, Dwayne R. Debarbieux, Laurent |
author_facet | Roach, Dwayne R. Debarbieux, Laurent |
author_sort | Roach, Dwayne R. |
collection | PubMed |
description | For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, both properly and improperly, antibiotic-resistant bacteria are becoming more prominent and represent a worldwide public health threat. Most importantly, new antibiotics are not progressing at the same rate as the emergence of resistance. The therapeutic modality of bacteriophages, called phage therapy, offers a clinical option to combat bacteria associated with diseases. Here, we discuss traditional phage therapy approaches, as well as how synthetic biology has allowed for the creation of designer phages for new clinical applications. To implement these technologies, several key aspects and challenges still need to be addressed, such as narrow spectrum, safety, and bacterial resistance. We will summarize our current understanding of how phage treatment elicits mammalian host immune responses, as well bacterial phage resistance development, and the potential impact each will have on phage therapy effectiveness. We conclude by discussing the need for a paradigm shift on how phage therapy strategies are developed. |
format | Online Article Text |
id | pubmed-7288995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72889952020-06-18 Phage therapy: awakening a sleeping giant Roach, Dwayne R. Debarbieux, Laurent Emerg Top Life Sci Review Articles For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, both properly and improperly, antibiotic-resistant bacteria are becoming more prominent and represent a worldwide public health threat. Most importantly, new antibiotics are not progressing at the same rate as the emergence of resistance. The therapeutic modality of bacteriophages, called phage therapy, offers a clinical option to combat bacteria associated with diseases. Here, we discuss traditional phage therapy approaches, as well as how synthetic biology has allowed for the creation of designer phages for new clinical applications. To implement these technologies, several key aspects and challenges still need to be addressed, such as narrow spectrum, safety, and bacterial resistance. We will summarize our current understanding of how phage treatment elicits mammalian host immune responses, as well bacterial phage resistance development, and the potential impact each will have on phage therapy effectiveness. We conclude by discussing the need for a paradigm shift on how phage therapy strategies are developed. Portland Press Ltd. 2017-04-21 2017-04-21 /pmc/articles/PMC7288995/ /pubmed/33525818 http://dx.doi.org/10.1042/ETLS20170002 Text en © 2017 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Articles Roach, Dwayne R. Debarbieux, Laurent Phage therapy: awakening a sleeping giant |
title | Phage therapy: awakening a sleeping giant |
title_full | Phage therapy: awakening a sleeping giant |
title_fullStr | Phage therapy: awakening a sleeping giant |
title_full_unstemmed | Phage therapy: awakening a sleeping giant |
title_short | Phage therapy: awakening a sleeping giant |
title_sort | phage therapy: awakening a sleeping giant |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288995/ https://www.ncbi.nlm.nih.gov/pubmed/33525818 http://dx.doi.org/10.1042/ETLS20170002 |
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