Cargando…

Double-Membrane Vesicles as Platforms for Viral Replication

Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a variety of fascinating ways. A striking example of this is the remodelling of intracellular membranes into specialized structures that support the replication of positive-sense ssRNA (+RNA) viruses infecting e...

Descripción completa

Detalles Bibliográficos
Autores principales: Wolff, Georg, Melia, Charlotte E., Snijder, Eric J., Bárcena, Montserrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289118/
https://www.ncbi.nlm.nih.gov/pubmed/32536523
http://dx.doi.org/10.1016/j.tim.2020.05.009
_version_ 1783545406338105344
author Wolff, Georg
Melia, Charlotte E.
Snijder, Eric J.
Bárcena, Montserrat
author_facet Wolff, Georg
Melia, Charlotte E.
Snijder, Eric J.
Bárcena, Montserrat
author_sort Wolff, Georg
collection PubMed
description Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a variety of fascinating ways. A striking example of this is the remodelling of intracellular membranes into specialized structures that support the replication of positive-sense ssRNA (+RNA) viruses infecting eukaryotes. These distinct forms of virus-induced structures include double-membrane vesicles (DMVs), found during viral infections as diverse and notorious as those of coronaviruses, enteroviruses, noroviruses, or hepatitis C virus. Our understanding of these DMVs has evolved over the past 15 years thanks to advances in imaging techniques and modern molecular biology tools. In this article, we review contemporary understanding of the biogenesis, structure, and function of virus-induced DMVs as well as the open questions posed by these intriguing structures.
format Online
Article
Text
id pubmed-7289118
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Authors. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-72891182020-06-12 Double-Membrane Vesicles as Platforms for Viral Replication Wolff, Georg Melia, Charlotte E. Snijder, Eric J. Bárcena, Montserrat Trends Microbiol Review Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a variety of fascinating ways. A striking example of this is the remodelling of intracellular membranes into specialized structures that support the replication of positive-sense ssRNA (+RNA) viruses infecting eukaryotes. These distinct forms of virus-induced structures include double-membrane vesicles (DMVs), found during viral infections as diverse and notorious as those of coronaviruses, enteroviruses, noroviruses, or hepatitis C virus. Our understanding of these DMVs has evolved over the past 15 years thanks to advances in imaging techniques and modern molecular biology tools. In this article, we review contemporary understanding of the biogenesis, structure, and function of virus-induced DMVs as well as the open questions posed by these intriguing structures. The Authors. Published by Elsevier Ltd. 2020-12 2020-06-11 /pmc/articles/PMC7289118/ /pubmed/32536523 http://dx.doi.org/10.1016/j.tim.2020.05.009 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Wolff, Georg
Melia, Charlotte E.
Snijder, Eric J.
Bárcena, Montserrat
Double-Membrane Vesicles as Platforms for Viral Replication
title Double-Membrane Vesicles as Platforms for Viral Replication
title_full Double-Membrane Vesicles as Platforms for Viral Replication
title_fullStr Double-Membrane Vesicles as Platforms for Viral Replication
title_full_unstemmed Double-Membrane Vesicles as Platforms for Viral Replication
title_short Double-Membrane Vesicles as Platforms for Viral Replication
title_sort double-membrane vesicles as platforms for viral replication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289118/
https://www.ncbi.nlm.nih.gov/pubmed/32536523
http://dx.doi.org/10.1016/j.tim.2020.05.009
work_keys_str_mv AT wolffgeorg doublemembranevesiclesasplatformsforviralreplication
AT meliacharlottee doublemembranevesiclesasplatformsforviralreplication
AT snijderericj doublemembranevesiclesasplatformsforviralreplication
AT barcenamontserrat doublemembranevesiclesasplatformsforviralreplication