Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast

INTRODUCTION: Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker. MATERIALS AND METHO...

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Detalles Bibliográficos
Autores principales: Singh, Shikha, Shukla, Samarth, Singh, Ashok, Acharya, Sourya, Kadu, R P, Bhake, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289207/
https://www.ncbi.nlm.nih.gov/pubmed/32566528
http://dx.doi.org/10.4103/ijabmr.IJABMR_349_18
Descripción
Sumario:INTRODUCTION: Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker. MATERIALS AND METHODS: All modified radical mastectomy cases with axillary lymph node dissection were taken. H and E staining was done. All lymph node-positive breast cancer cases were subjected to immunohistochemistry using ER and PR antibodies. RESULTS: In the study of 60 cases, the level of concordance between the primary tumor and the metastatic lymph node was 98.33% for ER and 96.66% for PR. CONCLUSION: There exists a positive correlation between the hormone receptor status of the primary tumor and the paired axillary lymph nodes.

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