Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast

INTRODUCTION: Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker. MATERIALS AND METHO...

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Autores principales: Singh, Shikha, Shukla, Samarth, Singh, Ashok, Acharya, Sourya, Kadu, R P, Bhake, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289207/
https://www.ncbi.nlm.nih.gov/pubmed/32566528
http://dx.doi.org/10.4103/ijabmr.IJABMR_349_18
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author Singh, Shikha
Shukla, Samarth
Singh, Ashok
Acharya, Sourya
Kadu, R P
Bhake, Arvind
author_facet Singh, Shikha
Shukla, Samarth
Singh, Ashok
Acharya, Sourya
Kadu, R P
Bhake, Arvind
author_sort Singh, Shikha
collection PubMed
description INTRODUCTION: Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker. MATERIALS AND METHODS: All modified radical mastectomy cases with axillary lymph node dissection were taken. H and E staining was done. All lymph node-positive breast cancer cases were subjected to immunohistochemistry using ER and PR antibodies. RESULTS: In the study of 60 cases, the level of concordance between the primary tumor and the metastatic lymph node was 98.33% for ER and 96.66% for PR. CONCLUSION: There exists a positive correlation between the hormone receptor status of the primary tumor and the paired axillary lymph nodes.
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spelling pubmed-72892072020-06-19 Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast Singh, Shikha Shukla, Samarth Singh, Ashok Acharya, Sourya Kadu, R P Bhake, Arvind Int J Appl Basic Med Res Original Article INTRODUCTION: Breast malignancy is a hormone-dependent tumor. The hormone receptor status in the primary tumor is required while taking decision for starting adjuvant therapy. The estrogen receptor (ER) and progesterone receptor (PR) status is also an important prognostic marker. MATERIALS AND METHODS: All modified radical mastectomy cases with axillary lymph node dissection were taken. H and E staining was done. All lymph node-positive breast cancer cases were subjected to immunohistochemistry using ER and PR antibodies. RESULTS: In the study of 60 cases, the level of concordance between the primary tumor and the metastatic lymph node was 98.33% for ER and 96.66% for PR. CONCLUSION: There exists a positive correlation between the hormone receptor status of the primary tumor and the paired axillary lymph nodes. Wolters Kluwer - Medknow 2020 2020-04-02 /pmc/articles/PMC7289207/ /pubmed/32566528 http://dx.doi.org/10.4103/ijabmr.IJABMR_349_18 Text en Copyright: © 2020 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Singh, Shikha
Shukla, Samarth
Singh, Ashok
Acharya, Sourya
Kadu, R P
Bhake, Arvind
Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title_full Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title_fullStr Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title_full_unstemmed Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title_short Comparison of Estrogen and Progesterone Receptor Status in Tumor Mass and Axillary Lymph Node Metastasis in Patients with Carcinoma Breast
title_sort comparison of estrogen and progesterone receptor status in tumor mass and axillary lymph node metastasis in patients with carcinoma breast
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289207/
https://www.ncbi.nlm.nih.gov/pubmed/32566528
http://dx.doi.org/10.4103/ijabmr.IJABMR_349_18
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