Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients

Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrimental effects on the quality of care and increased mortality. Social isolation strategies h...

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Autores principales: Convertino, Irma, Tuccori, Marco, Ferraro, Sara, Valdiserra, Giulia, Cappello, Emiliano, Focosi, Daniele, Blandizzi, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289228/
https://www.ncbi.nlm.nih.gov/pubmed/32527304
http://dx.doi.org/10.1186/s13054-020-03020-3
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author Convertino, Irma
Tuccori, Marco
Ferraro, Sara
Valdiserra, Giulia
Cappello, Emiliano
Focosi, Daniele
Blandizzi, Corrado
author_facet Convertino, Irma
Tuccori, Marco
Ferraro, Sara
Valdiserra, Giulia
Cappello, Emiliano
Focosi, Daniele
Blandizzi, Corrado
author_sort Convertino, Irma
collection PubMed
description Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrimental effects on the quality of care and increased mortality. Social isolation strategies have been implemented worldwide with the aim of reducing hospital pressure. Among therapeutic strategies, the use of immunomodulating drugs, to improve prognosis, seems promising. Particularly, since pneumonia and ARDS are associated with a cytokine storm, drugs belonging to therapeutic classes as anti-IL-6, anti-TNF, and JAK inhibitors are currently studied. In this article, we discuss the potential advantages of the most promising pharmacological approaches.
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spelling pubmed-72892282020-06-12 Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients Convertino, Irma Tuccori, Marco Ferraro, Sara Valdiserra, Giulia Cappello, Emiliano Focosi, Daniele Blandizzi, Corrado Crit Care Viewpoint Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrimental effects on the quality of care and increased mortality. Social isolation strategies have been implemented worldwide with the aim of reducing hospital pressure. Among therapeutic strategies, the use of immunomodulating drugs, to improve prognosis, seems promising. Particularly, since pneumonia and ARDS are associated with a cytokine storm, drugs belonging to therapeutic classes as anti-IL-6, anti-TNF, and JAK inhibitors are currently studied. In this article, we discuss the potential advantages of the most promising pharmacological approaches. BioMed Central 2020-06-11 /pmc/articles/PMC7289228/ /pubmed/32527304 http://dx.doi.org/10.1186/s13054-020-03020-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Viewpoint
Convertino, Irma
Tuccori, Marco
Ferraro, Sara
Valdiserra, Giulia
Cappello, Emiliano
Focosi, Daniele
Blandizzi, Corrado
Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title_full Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title_fullStr Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title_full_unstemmed Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title_short Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients
title_sort exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in covid-19 patients
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289228/
https://www.ncbi.nlm.nih.gov/pubmed/32527304
http://dx.doi.org/10.1186/s13054-020-03020-3
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