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Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T

Arterial spin-labeled magnetic resonance imaging can provide quantitative perfusion measurements in the brain and can be potentially used to evaluate therapy response assessment in glioblastoma (GBM). The reliability and reproducibility of this method to measure noncontrast perfusion in GBM, however...

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Autores principales: Zhou, Limin, Wang, Yiming, Pinho, Marco C., Pan, Edward, Xi, Yin, Maldjian, Joseph A., Madhuranthakam, Ananth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Grapho Publications, LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289238/
https://www.ncbi.nlm.nih.gov/pubmed/32548290
http://dx.doi.org/10.18383/j.tom.2020.00010
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author Zhou, Limin
Wang, Yiming
Pinho, Marco C.
Pan, Edward
Xi, Yin
Maldjian, Joseph A.
Madhuranthakam, Ananth J.
author_facet Zhou, Limin
Wang, Yiming
Pinho, Marco C.
Pan, Edward
Xi, Yin
Maldjian, Joseph A.
Madhuranthakam, Ananth J.
author_sort Zhou, Limin
collection PubMed
description Arterial spin-labeled magnetic resonance imaging can provide quantitative perfusion measurements in the brain and can be potentially used to evaluate therapy response assessment in glioblastoma (GBM). The reliability and reproducibility of this method to measure noncontrast perfusion in GBM, however, are lacking. We evaluated the intrasession reliability of brain and tumor perfusion in both healthy volunteers and patients with GBM at 3 T using pseudocontinuous labeling (pCASL) and 3D turbo spin echo (TSE) using Cartesian acquisition with spiral profile reordering (CASPR). Two healthy volunteers at a single time point and 6 newly diagnosed patients with GBM at multiple time points (before, during, and after chemoradiation) underwent scanning (total, 14 sessions). Compared with 3D GraSE, 3D TSE-CASPR generated cerebral blood flow maps with better tumor-to-normal background tissue contrast and reduced image distortions. The intraclass correlation coefficient between the 2 runs of 3D pCASL with TSE-CASPR was consistently high (≥0.90) across all normal-appearing gray matter (NAGM) regions of interest (ROIs), and was particularly high in tumors (0.98 with 95% confidence interval [CI]: 0.97–0.99). The within-subject coefficients of variation were relatively low in all normal-appearing gray matter regions of interest (3.40%–7.12%), and in tumors (4.91%). Noncontrast perfusion measured using 3D pCASL with TSE-CASPR provided robust cerebral blood flow maps in both healthy volunteers and patients with GBM with high intrasession repeatability at 3 T. This approach can be an appropriate noncontrast and noninvasive quantitative perfusion imaging method for longitudinal assessment of therapy response and management of patients with GBM.
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spelling pubmed-72892382020-06-15 Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T Zhou, Limin Wang, Yiming Pinho, Marco C. Pan, Edward Xi, Yin Maldjian, Joseph A. Madhuranthakam, Ananth J. Tomography Research Articles Arterial spin-labeled magnetic resonance imaging can provide quantitative perfusion measurements in the brain and can be potentially used to evaluate therapy response assessment in glioblastoma (GBM). The reliability and reproducibility of this method to measure noncontrast perfusion in GBM, however, are lacking. We evaluated the intrasession reliability of brain and tumor perfusion in both healthy volunteers and patients with GBM at 3 T using pseudocontinuous labeling (pCASL) and 3D turbo spin echo (TSE) using Cartesian acquisition with spiral profile reordering (CASPR). Two healthy volunteers at a single time point and 6 newly diagnosed patients with GBM at multiple time points (before, during, and after chemoradiation) underwent scanning (total, 14 sessions). Compared with 3D GraSE, 3D TSE-CASPR generated cerebral blood flow maps with better tumor-to-normal background tissue contrast and reduced image distortions. The intraclass correlation coefficient between the 2 runs of 3D pCASL with TSE-CASPR was consistently high (≥0.90) across all normal-appearing gray matter (NAGM) regions of interest (ROIs), and was particularly high in tumors (0.98 with 95% confidence interval [CI]: 0.97–0.99). The within-subject coefficients of variation were relatively low in all normal-appearing gray matter regions of interest (3.40%–7.12%), and in tumors (4.91%). Noncontrast perfusion measured using 3D pCASL with TSE-CASPR provided robust cerebral blood flow maps in both healthy volunteers and patients with GBM with high intrasession repeatability at 3 T. This approach can be an appropriate noncontrast and noninvasive quantitative perfusion imaging method for longitudinal assessment of therapy response and management of patients with GBM. Grapho Publications, LLC 2020-06 /pmc/articles/PMC7289238/ /pubmed/32548290 http://dx.doi.org/10.18383/j.tom.2020.00010 Text en © 2020 The Authors. Published by Grapho Publications, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Articles
Zhou, Limin
Wang, Yiming
Pinho, Marco C.
Pan, Edward
Xi, Yin
Maldjian, Joseph A.
Madhuranthakam, Ananth J.
Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title_full Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title_fullStr Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title_full_unstemmed Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title_short Intrasession Reliability of Arterial Spin-Labeled MRI–Measured Noncontrast Perfusion in Glioblastoma at 3 T
title_sort intrasession reliability of arterial spin-labeled mri–measured noncontrast perfusion in glioblastoma at 3 t
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289238/
https://www.ncbi.nlm.nih.gov/pubmed/32548290
http://dx.doi.org/10.18383/j.tom.2020.00010
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