Cargando…

The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry

BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limi...

Descripción completa

Detalles Bibliográficos
Autores principales: Meindl, Christine, Hochadel, Matthias, Frankenstein, Lutz, Bruder, Oliver, Pauschinger, Matthias, Hambrecht, Rainer, von Scheidt, Wolfgang, Pfister, Otmar, Hartmann, Andreas, Maier, Lars S., Senges, Jochen, Unsöld, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289353/
https://www.ncbi.nlm.nih.gov/pubmed/32525964
http://dx.doi.org/10.1371/journal.pone.0234260
_version_ 1783545444471668736
author Meindl, Christine
Hochadel, Matthias
Frankenstein, Lutz
Bruder, Oliver
Pauschinger, Matthias
Hambrecht, Rainer
von Scheidt, Wolfgang
Pfister, Otmar
Hartmann, Andreas
Maier, Lars S.
Senges, Jochen
Unsöld, Bernhard
author_facet Meindl, Christine
Hochadel, Matthias
Frankenstein, Lutz
Bruder, Oliver
Pauschinger, Matthias
Hambrecht, Rainer
von Scheidt, Wolfgang
Pfister, Otmar
Hartmann, Andreas
Maier, Lars S.
Senges, Jochen
Unsöld, Bernhard
author_sort Meindl, Christine
collection PubMed
description BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM). METHODS: EVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure. RESULTS: Between February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, p<0.001, n = 885). In contrast the mortality rate of patients with IHD was not influenced by the presence of diabetes (17.6% in patients with IHD and diabetes n = 945, vs. 14.7% in patients with IHD and no diabetes, n = 1236, p = 0.061). The results also remained stable after performing a multivariable analysis (unadjusted p-value for interaction = 0.002, adjusted p = 0.046). CONCLUSION: The influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome.
format Online
Article
Text
id pubmed-7289353
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-72893532020-06-15 The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry Meindl, Christine Hochadel, Matthias Frankenstein, Lutz Bruder, Oliver Pauschinger, Matthias Hambrecht, Rainer von Scheidt, Wolfgang Pfister, Otmar Hartmann, Andreas Maier, Lars S. Senges, Jochen Unsöld, Bernhard PLoS One Research Article BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM). METHODS: EVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure. RESULTS: Between February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, p<0.001, n = 885). In contrast the mortality rate of patients with IHD was not influenced by the presence of diabetes (17.6% in patients with IHD and diabetes n = 945, vs. 14.7% in patients with IHD and no diabetes, n = 1236, p = 0.061). The results also remained stable after performing a multivariable analysis (unadjusted p-value for interaction = 0.002, adjusted p = 0.046). CONCLUSION: The influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome. Public Library of Science 2020-06-11 /pmc/articles/PMC7289353/ /pubmed/32525964 http://dx.doi.org/10.1371/journal.pone.0234260 Text en © 2020 Meindl et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Meindl, Christine
Hochadel, Matthias
Frankenstein, Lutz
Bruder, Oliver
Pauschinger, Matthias
Hambrecht, Rainer
von Scheidt, Wolfgang
Pfister, Otmar
Hartmann, Andreas
Maier, Lars S.
Senges, Jochen
Unsöld, Bernhard
The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title_full The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title_fullStr The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title_full_unstemmed The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title_short The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
title_sort role of diabetes in cardiomyopathies of different etiologies—characteristics and 1-year follow-up results of the evita-hf registry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289353/
https://www.ncbi.nlm.nih.gov/pubmed/32525964
http://dx.doi.org/10.1371/journal.pone.0234260
work_keys_str_mv AT meindlchristine theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hochadelmatthias theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT frankensteinlutz theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT bruderoliver theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT pauschingermatthias theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hambrechtrainer theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT vonscheidtwolfgang theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT pfisterotmar theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hartmannandreas theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT maierlarss theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT sengesjochen theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT unsoldbernhard theroleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT meindlchristine roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hochadelmatthias roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT frankensteinlutz roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT bruderoliver roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT pauschingermatthias roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hambrechtrainer roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT vonscheidtwolfgang roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT pfisterotmar roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT hartmannandreas roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT maierlarss roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT sengesjochen roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry
AT unsoldbernhard roleofdiabetesincardiomyopathiesofdifferentetiologiescharacteristicsand1yearfollowupresultsoftheevitahfregistry