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The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry
BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289353/ https://www.ncbi.nlm.nih.gov/pubmed/32525964 http://dx.doi.org/10.1371/journal.pone.0234260 |
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author | Meindl, Christine Hochadel, Matthias Frankenstein, Lutz Bruder, Oliver Pauschinger, Matthias Hambrecht, Rainer von Scheidt, Wolfgang Pfister, Otmar Hartmann, Andreas Maier, Lars S. Senges, Jochen Unsöld, Bernhard |
author_facet | Meindl, Christine Hochadel, Matthias Frankenstein, Lutz Bruder, Oliver Pauschinger, Matthias Hambrecht, Rainer von Scheidt, Wolfgang Pfister, Otmar Hartmann, Andreas Maier, Lars S. Senges, Jochen Unsöld, Bernhard |
author_sort | Meindl, Christine |
collection | PubMed |
description | BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM). METHODS: EVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure. RESULTS: Between February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, p<0.001, n = 885). In contrast the mortality rate of patients with IHD was not influenced by the presence of diabetes (17.6% in patients with IHD and diabetes n = 945, vs. 14.7% in patients with IHD and no diabetes, n = 1236, p = 0.061). The results also remained stable after performing a multivariable analysis (unadjusted p-value for interaction = 0.002, adjusted p = 0.046). CONCLUSION: The influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome. |
format | Online Article Text |
id | pubmed-7289353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72893532020-06-15 The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry Meindl, Christine Hochadel, Matthias Frankenstein, Lutz Bruder, Oliver Pauschinger, Matthias Hambrecht, Rainer von Scheidt, Wolfgang Pfister, Otmar Hartmann, Andreas Maier, Lars S. Senges, Jochen Unsöld, Bernhard PLoS One Research Article BACKGROUND: Type 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM). METHODS: EVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure. RESULTS: Between February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, p<0.001, n = 885). In contrast the mortality rate of patients with IHD was not influenced by the presence of diabetes (17.6% in patients with IHD and diabetes n = 945, vs. 14.7% in patients with IHD and no diabetes, n = 1236, p = 0.061). The results also remained stable after performing a multivariable analysis (unadjusted p-value for interaction = 0.002, adjusted p = 0.046). CONCLUSION: The influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome. Public Library of Science 2020-06-11 /pmc/articles/PMC7289353/ /pubmed/32525964 http://dx.doi.org/10.1371/journal.pone.0234260 Text en © 2020 Meindl et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Meindl, Christine Hochadel, Matthias Frankenstein, Lutz Bruder, Oliver Pauschinger, Matthias Hambrecht, Rainer von Scheidt, Wolfgang Pfister, Otmar Hartmann, Andreas Maier, Lars S. Senges, Jochen Unsöld, Bernhard The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title | The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title_full | The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title_fullStr | The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title_full_unstemmed | The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title_short | The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry |
title_sort | role of diabetes in cardiomyopathies of different etiologies—characteristics and 1-year follow-up results of the evita-hf registry |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289353/ https://www.ncbi.nlm.nih.gov/pubmed/32525964 http://dx.doi.org/10.1371/journal.pone.0234260 |
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