Endogenous Oligodendroglial Alpha-Synuclein and TPPP/p25α Orchestrate Alpha-Synuclein Pathology in Experimental Multiple System Atrophy Models

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and...

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Detalles Bibliográficos
Autores principales: Mavroeidi, Panagiota, Arvanitaki, Fedra, Karakitsou, Anastasia-Kiriaki, Vetsi, Maria, Kloukina, Ismini, Zweckstetter, Markus, Giller, Karin, Becker, Stefan, Sorrentino, Zachary A., Giasson, Benoit I., Henning Jensen, Poul, Stefanis, Leonidas, Xilouri, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289399/
https://www.ncbi.nlm.nih.gov/pubmed/31011860
http://dx.doi.org/10.1007/s00401-019-02014-y

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