Bromodomain AAA+ ATPases get into shape

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM struct...

Descripción completa

Detalles Bibliográficos
Autores principales: Murawska, Magdalena, Ladurner, Andreas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289582/
https://www.ncbi.nlm.nih.gov/pubmed/32191554
http://dx.doi.org/10.1080/19491034.2020.1741304
_version_ 1783545490685558784
author Murawska, Magdalena
Ladurner, Andreas G.
author_facet Murawska, Magdalena
Ladurner, Andreas G.
author_sort Murawska, Magdalena
collection PubMed
description Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.
format Online
Article
Text
id pubmed-7289582
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-72895822020-06-22 Bromodomain AAA+ ATPases get into shape Murawska, Magdalena Ladurner, Andreas G. Nucleus Commentary Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone. Taylor & Francis 2020-03-19 /pmc/articles/PMC7289582/ /pubmed/32191554 http://dx.doi.org/10.1080/19491034.2020.1741304 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Murawska, Magdalena
Ladurner, Andreas G.
Bromodomain AAA+ ATPases get into shape
title Bromodomain AAA+ ATPases get into shape
title_full Bromodomain AAA+ ATPases get into shape
title_fullStr Bromodomain AAA+ ATPases get into shape
title_full_unstemmed Bromodomain AAA+ ATPases get into shape
title_short Bromodomain AAA+ ATPases get into shape
title_sort bromodomain aaa+ atpases get into shape
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289582/
https://www.ncbi.nlm.nih.gov/pubmed/32191554
http://dx.doi.org/10.1080/19491034.2020.1741304
work_keys_str_mv AT murawskamagdalena bromodomainaaaatpasesgetintoshape
AT ladurnerandreasg bromodomainaaaatpasesgetintoshape

Ejemplares similares