KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TEs. We demonstrate that many recently emerged...

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Detalles Bibliográficos
Autores principales: Wolf, Gernot, de Iaco, Alberto, Sun, Ming-An, Bruno, Melania, Tinkham, Matthew, Hoang, Don, Mitra, Apratim, Ralls, Sherry, Trono, Didier, Macfarlan, Todd S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289599/
https://www.ncbi.nlm.nih.gov/pubmed/32479262
http://dx.doi.org/10.7554/eLife.56337

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