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Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography

OBJECTIVE: To assess the diagnostic performance of a deep learning-based algorithm for automated detection of acute and chronic rib fractures on whole-body trauma CT. MATERIALS AND METHODS: We retrospectively identified all whole-body trauma CT scans referred from the emergency department of our hos...

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Autores principales: Weikert, Thomas, Noordtzij, Luca Andre, Bremerich, Jens, Stieltjes, Bram, Parmar, Victor, Cyriac, Joshy, Sommer, Gregor, Sauter, Alexander Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289702/
https://www.ncbi.nlm.nih.gov/pubmed/32524789
http://dx.doi.org/10.3348/kjr.2019.0653
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author Weikert, Thomas
Noordtzij, Luca Andre
Bremerich, Jens
Stieltjes, Bram
Parmar, Victor
Cyriac, Joshy
Sommer, Gregor
Sauter, Alexander Walter
author_facet Weikert, Thomas
Noordtzij, Luca Andre
Bremerich, Jens
Stieltjes, Bram
Parmar, Victor
Cyriac, Joshy
Sommer, Gregor
Sauter, Alexander Walter
author_sort Weikert, Thomas
collection PubMed
description OBJECTIVE: To assess the diagnostic performance of a deep learning-based algorithm for automated detection of acute and chronic rib fractures on whole-body trauma CT. MATERIALS AND METHODS: We retrospectively identified all whole-body trauma CT scans referred from the emergency department of our hospital from January to December 2018 (n = 511). Scans were categorized as positive (n = 159) or negative (n = 352) for rib fractures according to the clinically approved written CT reports, which served as the index test. The bone kernel series (1.5-mm slice thickness) served as an input for a detection prototype algorithm trained to detect both acute and chronic rib fractures based on a deep convolutional neural network. It had previously been trained on an independent sample from eight other institutions (n = 11455). RESULTS: All CTs except one were successfully processed (510/511). The algorithm achieved a sensitivity of 87.4% and specificity of 91.5% on a per-examination level [per CT scan: rib fracture(s): yes/no]. There were 0.16 false-positives per examination (= 81/510). On a per-finding level, there were 587 true-positive findings (sensitivity: 65.7%) and 307 false-negatives. Furthermore, 97 true rib fractures were detected that were not mentioned in the written CT reports. A major factor associated with correct detection was displacement. CONCLUSION: We found good performance of a deep learning-based prototype algorithm detecting rib fractures on trauma CT on a per-examination level at a low rate of false-positives per case. A potential area for clinical application is its use as a screening tool to avoid false-negative radiology reports.
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spelling pubmed-72897022020-07-01 Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography Weikert, Thomas Noordtzij, Luca Andre Bremerich, Jens Stieltjes, Bram Parmar, Victor Cyriac, Joshy Sommer, Gregor Sauter, Alexander Walter Korean J Radiol Thoracic Imaging OBJECTIVE: To assess the diagnostic performance of a deep learning-based algorithm for automated detection of acute and chronic rib fractures on whole-body trauma CT. MATERIALS AND METHODS: We retrospectively identified all whole-body trauma CT scans referred from the emergency department of our hospital from January to December 2018 (n = 511). Scans were categorized as positive (n = 159) or negative (n = 352) for rib fractures according to the clinically approved written CT reports, which served as the index test. The bone kernel series (1.5-mm slice thickness) served as an input for a detection prototype algorithm trained to detect both acute and chronic rib fractures based on a deep convolutional neural network. It had previously been trained on an independent sample from eight other institutions (n = 11455). RESULTS: All CTs except one were successfully processed (510/511). The algorithm achieved a sensitivity of 87.4% and specificity of 91.5% on a per-examination level [per CT scan: rib fracture(s): yes/no]. There were 0.16 false-positives per examination (= 81/510). On a per-finding level, there were 587 true-positive findings (sensitivity: 65.7%) and 307 false-negatives. Furthermore, 97 true rib fractures were detected that were not mentioned in the written CT reports. A major factor associated with correct detection was displacement. CONCLUSION: We found good performance of a deep learning-based prototype algorithm detecting rib fractures on trauma CT on a per-examination level at a low rate of false-positives per case. A potential area for clinical application is its use as a screening tool to avoid false-negative radiology reports. The Korean Society of Radiology 2020-07 2019-06-05 /pmc/articles/PMC7289702/ /pubmed/32524789 http://dx.doi.org/10.3348/kjr.2019.0653 Text en Copyright © 2020 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Thoracic Imaging
Weikert, Thomas
Noordtzij, Luca Andre
Bremerich, Jens
Stieltjes, Bram
Parmar, Victor
Cyriac, Joshy
Sommer, Gregor
Sauter, Alexander Walter
Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title_full Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title_fullStr Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title_full_unstemmed Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title_short Assessment of a Deep Learning Algorithm for the Detection of Rib Fractures on Whole-Body Trauma Computed Tomography
title_sort assessment of a deep learning algorithm for the detection of rib fractures on whole-body trauma computed tomography
topic Thoracic Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289702/
https://www.ncbi.nlm.nih.gov/pubmed/32524789
http://dx.doi.org/10.3348/kjr.2019.0653
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