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Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years
BACKGROUND: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid to its epidemiology and clinical characteristics in children. However, it is also crucial for clinicians to differentiate COVID-19 from other respiratory infectious diseases, such as...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289729/ https://www.ncbi.nlm.nih.gov/pubmed/32535301 http://dx.doi.org/10.1016/j.ijid.2020.06.026 |
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author | Li, Ying Wang, Haizhou Wang, Fan Du, Hui Liu, Xueru Chen, Peng Wang, Yanli Lu, Xiaoxia |
author_facet | Li, Ying Wang, Haizhou Wang, Fan Du, Hui Liu, Xueru Chen, Peng Wang, Yanli Lu, Xiaoxia |
author_sort | Li, Ying |
collection | PubMed |
description | BACKGROUND: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid to its epidemiology and clinical characteristics in children. However, it is also crucial for clinicians to differentiate COVID-19 from other respiratory infectious diseases, such as influenza viruses. METHODS: This was a retrospective study. Two groups of COVID-19 patients (n = 57) and influenza A patients (n = 59) were enrolled. We analyzed and compared their clinical manifestations, imaging characteristics and treatments. RESULTS: The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P < 0.001; 84.7%, P < 0.001; and 35.6%, P = 0.007; respectively). In addition, COVID-19 patients showed significantly lower levels of leukocytes (7.87 vs. 9.89 × 10(9) L(–1), P = 0.027), neutrophils (2.43 vs. 5.16 × 10(9) L(–1), P < 0.001), C-reactive protein (CRP; 3.7 vs. 15.1 mg/L, P = 0.001) and procalcitonin (PCT; 0.09 vs. 0.68 mm/h, P < 0.001), while lymphocyte levels (4.58 vs. 3.56 × 109 L(–1); P = 0.006) were significantly higher compared with influenza A patients. In terms of CT imaging, ground-glass opacification in chest CT was more common in COVID-19 patients than in influenza A patients (42.1% vs. 15%, P = 0.032). In contrast, consolidation was more common in influenza A patients (25%) than in COVID-19 patients (5.2%, P = 0.025). CONCLUSION: The clinical manifestations and laboratory tests of COVID-19 children are milder than those of influenza A children under 5 years. Additionally, imaging results more commonly presented as ground-glass opacities in COVID-19 patients. |
format | Online Article Text |
id | pubmed-7289729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72897292020-06-12 Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years Li, Ying Wang, Haizhou Wang, Fan Du, Hui Liu, Xueru Chen, Peng Wang, Yanli Lu, Xiaoxia Int J Infect Dis Article BACKGROUND: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid to its epidemiology and clinical characteristics in children. However, it is also crucial for clinicians to differentiate COVID-19 from other respiratory infectious diseases, such as influenza viruses. METHODS: This was a retrospective study. Two groups of COVID-19 patients (n = 57) and influenza A patients (n = 59) were enrolled. We analyzed and compared their clinical manifestations, imaging characteristics and treatments. RESULTS: The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P < 0.001; 84.7%, P < 0.001; and 35.6%, P = 0.007; respectively). In addition, COVID-19 patients showed significantly lower levels of leukocytes (7.87 vs. 9.89 × 10(9) L(–1), P = 0.027), neutrophils (2.43 vs. 5.16 × 10(9) L(–1), P < 0.001), C-reactive protein (CRP; 3.7 vs. 15.1 mg/L, P = 0.001) and procalcitonin (PCT; 0.09 vs. 0.68 mm/h, P < 0.001), while lymphocyte levels (4.58 vs. 3.56 × 109 L(–1); P = 0.006) were significantly higher compared with influenza A patients. In terms of CT imaging, ground-glass opacification in chest CT was more common in COVID-19 patients than in influenza A patients (42.1% vs. 15%, P = 0.032). In contrast, consolidation was more common in influenza A patients (25%) than in COVID-19 patients (5.2%, P = 0.025). CONCLUSION: The clinical manifestations and laboratory tests of COVID-19 children are milder than those of influenza A children under 5 years. Additionally, imaging results more commonly presented as ground-glass opacities in COVID-19 patients. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-09 2020-06-12 /pmc/articles/PMC7289729/ /pubmed/32535301 http://dx.doi.org/10.1016/j.ijid.2020.06.026 Text en © 2020 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Li, Ying Wang, Haizhou Wang, Fan Du, Hui Liu, Xueru Chen, Peng Wang, Yanli Lu, Xiaoxia Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title | Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title_full | Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title_fullStr | Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title_full_unstemmed | Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title_short | Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years |
title_sort | comparison of hospitalized patients with pneumonia caused by covid-19 and influenza a in children under 5 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289729/ https://www.ncbi.nlm.nih.gov/pubmed/32535301 http://dx.doi.org/10.1016/j.ijid.2020.06.026 |
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