Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling

A phase 1 clinical trial in healthy male volunteers was conducted with a somatostatin-dopamine chimera (BIM23B065), from which information could be obtained on the concentration-effect relationship of the inhibition of pulsatile endogenous growth hormone and prolactin secretion. Endogenous growth ho...

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Detalles Bibliográficos
Autores principales: van Esdonk, Michiel J., Burggraaf, Jacobus, Dehez, Marion, van der Graaf, Piet H., Stevens, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289785/
https://www.ncbi.nlm.nih.gov/pubmed/32248329
http://dx.doi.org/10.1007/s10928-020-09683-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289785/
https://www.ncbi.nlm.nih.gov/pubmed/32248329
http://dx.doi.org/10.1007/s10928-020-09683-3

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