Cargando…

Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia

Relevant molecular tools for treatment stratification of patients ≥65 years with acute myeloid leukemia (AML) are lacking. We combined clinical data with targeted DNA- and full RNA-sequencing of 182 intensively and palliatively treated patients to predict complete remission (CR) and survival in AML...

Descripción completa

Detalles Bibliográficos
Autores principales:	Österroos, Albin, Björklund, My, Eriksson, Anna, Lindberg, Johan, Nilsson, Christer, Mareschal, Sylvain, Rantalainen, Mattias, Grönberg, Henrik, Lehmann, Sören
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289793/ https://www.ncbi.nlm.nih.gov/pubmed/32527994 http://dx.doi.org/10.1038/s41408-020-0332-3

Ejemplares similares

Development and Validation of a Novel RNA Sequencing–Based Prognostic Score for Acute Myeloid Leukemia
por: Wang, Mei, et al.
Publicado: (2018)

Expression levels of long non-coding RNAs are prognostic for AML outcome
por: Mer, Arvind Singh, et al.
Publicado: (2018)

Prediction model for drug response of acute myeloid leukemia patients
por: Trac, Quang Thinh, et al.
Publicado: (2023)

Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling
por: Wang, M, et al.
Publicado: (2017)

P513: MOLECULAR PATTERN BY AGE AND OVERALL SURVIVAL IN ACUTE MYELOID LEUKEMIA: A POPULATION-BASED STUDY FROM THE SWEDISH AML REGISTRY.
por: Juliusson, Gunnar, et al.
Publicado: (2023)

Determining breast cancer histological grade from RNA-sequencing data
por: Wang, Mei, et al.
Publicado: (2016)

Transcriptome-wide prediction of prostate cancer gene expression from histopathology images using co-expression-based convolutional neural networks
por: Weitz, Philippe, et al.
Publicado: (2022)

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
por: Eriksson, A, et al.
Publicado: (2015)

Using deep learning to detect patients at risk for prostate cancer despite benign biopsies
por: Liu, Bojing, et al.
Publicado: (2022)

Spontaneous hematological remission of acute myeloid leukemia
por: Kaźmierczak, Maciej, et al.
Publicado: (2014)

Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
por: Nilsson, Christer, et al.
Publicado: (2022)

The concept of treatment-free remission in chronic myeloid leukemia
por: Saußele, S, et al.
Publicado: (2016)

What is treatment free remission in chronic myeloid leukemia?
por: Rea, Delphine, et al.
Publicado: (2017)

Study design requirements for RNA sequencing-based breast cancer diagnostics
por: Mer, Arvind Singh, et al.
Publicado: (2016)

Durable remission of acute myeloid leukemia in an elderly patient following a limited course of azacitidine and venetoclax
por: Ehsan, Hamid, et al.
Publicado: (2022)

A risk score based on real-world data to predict early death in acute promyelocytic leukemia
por: Österroos, Albin, et al.
Publicado: (2022)

Treatment free remission in chronic myeloid leukemia: Lights and shadows
por: Molica, Matteo, et al.
Publicado: (2020)

Spontaneous remission of acute myeloid leukemia with NF1 alteration
por: Bradley, Terrence, et al.
Publicado: (2020)

Spontaneous Remission of Acute Myeloid Leukemia: A Case Report
por: Martínez-Díez, Yolanda, et al.
Publicado: (2022)

Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
por: Rantalainen, Mattias, et al.
Publicado: (2016)

Age and remission induction therapy for acute myeloid leukemia: An analysis of data from the Korean acute myeloid leukemia registry
por: Yoo, Kwai Han, et al.
Publicado: (2021)

Planned Pregnancy in a Chronic Myeloid Leukemia Patient in Molecular Remission
por: Pavlovsky, Carolina, et al.
Publicado: (2012)

Deep molecular responses for treatment‐free remission in chronic myeloid leukemia
por: Dulucq, Stéphanie, et al.
Publicado: (2016)

Optimizing survival outcomes with post‐remission therapy in acute myeloid leukemia
por: Medeiros, Bruno C., et al.
Publicado: (2019)

Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission
por: Hughes, Amy, et al.
Publicado: (2017)

Treatment-Free Remission in Chronic Myeloid Leukemia and New Approaches by Targeting Leukemia Stem Cells
por: Chen, Yilin, et al.
Publicado: (2021)

Hypoplastic acute myeloid leukemia in an elderly patient. A long‐term partial remission with low‐dose prednisone and G‐CSF
por: Islam, Anwarul
Publicado: (2019)

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia
por: van de Loosdrecht, Arjan A., et al.
Publicado: (2018)

Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis
por: Mozafari, Rambod, et al.
Publicado: (2017)

Treatment-Free Remission—A New Aim in the Treatment of Chronic Myeloid Leukemia
por: Kwaśnik, Paulina, et al.
Publicado: (2021)

Onset of blast crisis in chronic myeloid leukemia patients in treatment-free remission
por: Dulucq, Stephanie, et al.
Publicado: (2022)

Spontaneous Remission in a Patient with Chronic Myeloid Leukemia: A Case Report
por: Alshurafa, Awni, et al.
Publicado: (2023)

Chasing quality remission in acute myeloid leukemia: intensity of induction and residual disease
por: Ofran, Yishai
Publicado: (2023)

Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells
por: Hultmark, Simon, et al.
Publicado: (2020)

Leukemia Stem Cells as a Potential Target to Achieve Therapy-Free Remission in Chronic Myeloid Leukemia
por: Ito, Kyoko, et al.
Publicado: (2021)

Acute Myeloid Leukemia Transformation from Myelofibrosis Upon Remission of an Orbital Myeloid Sarcoma – A Case Report
por: Chen, Nancy, et al.
Publicado: (2021)

Association of leukocyte nadir with complete remission in Indonesian acute myeloid leukemia patients undergoing 7+3 remission induction chemotherapy
por: Hadisantoso, Dwi Wahyunianto, et al.
Publicado: (2022)

Evaluation of X-Chromosome Inactivation Patterns in Patients with Acute Myeloid Leukemia during Remission
por: Mortazavi, Yousef, et al.
Publicado: (2012)

Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients
por: Caocci, Giovanni, et al.
Publicado: (2016)

Chronic myeloid leukemia patients and treatment-free remission attitudes: a multicenter survey
por: Lou, Jin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a0h3j5otu00mdcion67dmd3t0e