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Probing the Structural Dynamics of the Catalytic Domain of Human Soluble Guanylate Cyclase

In the nitric oxide (NO) signaling pathway, human soluble guanylate cyclase (hsGC) synthesizes cyclic guanosine monophosphate (cGMP); responsible for the regulation of cGMP-specific protein kinases (PKGs) and phosphodiesterases (PDEs). The crystal structure of the inactive hsGC cyclase dimer is know...

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Detalles Bibliográficos
Autores principales:	Khalid, Rana Rehan, Maryam, Arooma, Sezerman, Osman Ugur, Mylonas, Efstratios, Siddiqi, Abdul Rauf, Kokkinidis, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289801/ https://www.ncbi.nlm.nih.gov/pubmed/32528025 http://dx.doi.org/10.1038/s41598-020-66310-4

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