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Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer

The usefulness of PET/MRI in head and neck malignancy has not been fully elucidated. The purpose of our study was to evaluate the diagnostic accuracy and confidence of PET/MRI in comparison with PET or MRI alone. This study included 73 consecutive patients who underwent [18F] FDG PET/MRI in head and...

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Autores principales: Park, Jisang, Pak, Kyoungjune, Yun, Tae Jin, Lee, Eun Kyoung, Ryoo, Inseon, Lee, Ji Ye, Hwang, Inpyeong, Yoo, Roh-Eul, Kang, Koung Mi, Choi, Seung Hong, Sohn, Chul-Ho, Cheon, Gi Jeong, Kim, Ji-hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289810/
https://www.ncbi.nlm.nih.gov/pubmed/32528161
http://dx.doi.org/10.1038/s41598-020-66506-8
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author Park, Jisang
Pak, Kyoungjune
Yun, Tae Jin
Lee, Eun Kyoung
Ryoo, Inseon
Lee, Ji Ye
Hwang, Inpyeong
Yoo, Roh-Eul
Kang, Koung Mi
Choi, Seung Hong
Sohn, Chul-Ho
Cheon, Gi Jeong
Kim, Ji-hoon
author_facet Park, Jisang
Pak, Kyoungjune
Yun, Tae Jin
Lee, Eun Kyoung
Ryoo, Inseon
Lee, Ji Ye
Hwang, Inpyeong
Yoo, Roh-Eul
Kang, Koung Mi
Choi, Seung Hong
Sohn, Chul-Ho
Cheon, Gi Jeong
Kim, Ji-hoon
author_sort Park, Jisang
collection PubMed
description The usefulness of PET/MRI in head and neck malignancy has not been fully elucidated. The purpose of our study was to evaluate the diagnostic accuracy and confidence of PET/MRI in comparison with PET or MRI alone. This study included 73 consecutive patients who underwent [18F] FDG PET/MRI in head and neck under the suspicion of malignancy. A neuroradiologist and a nuclear medicine specialist reviewed MRI and PET images, respectively and independently, followed by a consensus review of PET/MRI one month later. For 134 lesions, accuracy and confidence were compared among PET, MRI, and PET/MRI. For lesion base, PET/MRI had a sensitivity of 85.7%, a specificity of 89.1%, a PPV of 89.6%, a negative predictive value of 85.1%, and an accuracy of 87.3%. AUCs of PET/MRI per lesion (0.926) and per patient (0.934) for diagnosing malignancy were higher than PET (0.847 and 0.747, respectively) or MRI (0.836 and 0.798, respectively) alone (P < 0.05). More than 80% of the cases (111/134) showed diagnostic concordance between PET and MRI. PPV of PET/MRI was higher in malignant concordant cases (93.2%, 55/59) than in discordant cases (62.5%, 5/8) (p = 0.040). Confident scoring rate in malignant concordant cases was higher on PET/MRI (96.6%, 57/59) than on MRI (76.3%, 45/59) (p = 0.003). In conclusion, compared with PET or MRI alone, PET/MRI presents better diagnostic performance in accuracy and confidence for diagnosis of malignancy. PET/MRI is useful in patients with head and neck cancer.
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spelling pubmed-72898102020-06-15 Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer Park, Jisang Pak, Kyoungjune Yun, Tae Jin Lee, Eun Kyoung Ryoo, Inseon Lee, Ji Ye Hwang, Inpyeong Yoo, Roh-Eul Kang, Koung Mi Choi, Seung Hong Sohn, Chul-Ho Cheon, Gi Jeong Kim, Ji-hoon Sci Rep Article The usefulness of PET/MRI in head and neck malignancy has not been fully elucidated. The purpose of our study was to evaluate the diagnostic accuracy and confidence of PET/MRI in comparison with PET or MRI alone. This study included 73 consecutive patients who underwent [18F] FDG PET/MRI in head and neck under the suspicion of malignancy. A neuroradiologist and a nuclear medicine specialist reviewed MRI and PET images, respectively and independently, followed by a consensus review of PET/MRI one month later. For 134 lesions, accuracy and confidence were compared among PET, MRI, and PET/MRI. For lesion base, PET/MRI had a sensitivity of 85.7%, a specificity of 89.1%, a PPV of 89.6%, a negative predictive value of 85.1%, and an accuracy of 87.3%. AUCs of PET/MRI per lesion (0.926) and per patient (0.934) for diagnosing malignancy were higher than PET (0.847 and 0.747, respectively) or MRI (0.836 and 0.798, respectively) alone (P < 0.05). More than 80% of the cases (111/134) showed diagnostic concordance between PET and MRI. PPV of PET/MRI was higher in malignant concordant cases (93.2%, 55/59) than in discordant cases (62.5%, 5/8) (p = 0.040). Confident scoring rate in malignant concordant cases was higher on PET/MRI (96.6%, 57/59) than on MRI (76.3%, 45/59) (p = 0.003). In conclusion, compared with PET or MRI alone, PET/MRI presents better diagnostic performance in accuracy and confidence for diagnosis of malignancy. PET/MRI is useful in patients with head and neck cancer. Nature Publishing Group UK 2020-06-11 /pmc/articles/PMC7289810/ /pubmed/32528161 http://dx.doi.org/10.1038/s41598-020-66506-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Park, Jisang
Pak, Kyoungjune
Yun, Tae Jin
Lee, Eun Kyoung
Ryoo, Inseon
Lee, Ji Ye
Hwang, Inpyeong
Yoo, Roh-Eul
Kang, Koung Mi
Choi, Seung Hong
Sohn, Chul-Ho
Cheon, Gi Jeong
Kim, Ji-hoon
Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title_full Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title_fullStr Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title_full_unstemmed Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title_short Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in comparison with PET or MRI alone in Head and Neck Cancer
title_sort diagnostic accuracy and confidence of [18f] fdg pet/mri in comparison with pet or mri alone in head and neck cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289810/
https://www.ncbi.nlm.nih.gov/pubmed/32528161
http://dx.doi.org/10.1038/s41598-020-66506-8
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