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The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer
A bridge to surgery (BTS) after a colonic stent for obstructive colon cancer has not been accepted as a standard treatment strategy. Also, there is no consensus regarding the optimal time interval for BTS. We aimed to identify the optimal timing for BTS after stent placement to decrease the oncologi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289825/ https://www.ncbi.nlm.nih.gov/pubmed/32528099 http://dx.doi.org/10.1038/s41598-020-66508-6 |
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author | Kye, Bong-Hyeon Kim, Ji-Hoon Kim, Hyung-Jin Lee, Yoon Suk Lee, In-Kyu Kang, Won Kyung Cho, Hyeon-Min Ahn, Chang-Hyeok Oh, Seong-Taek |
author_facet | Kye, Bong-Hyeon Kim, Ji-Hoon Kim, Hyung-Jin Lee, Yoon Suk Lee, In-Kyu Kang, Won Kyung Cho, Hyeon-Min Ahn, Chang-Hyeok Oh, Seong-Taek |
author_sort | Kye, Bong-Hyeon |
collection | PubMed |
description | A bridge to surgery (BTS) after a colonic stent for obstructive colon cancer has not been accepted as a standard treatment strategy. Also, there is no consensus regarding the optimal time interval for BTS. We aimed to identify the optimal timing for BTS after stent placement to decrease the oncologic risk. We retrospectively collected data of 174 patients who underwent BTS after stent placement for stage II or III obstructive colon cancer from five hospitals. We divided the patients into three groups based on the time interval for BTS after stent placement: within 7 days (Group 1), from 8 to 14 days (Group 2), and after 14 days (Group 3). The primary outcome was to compare the oncologic outcomes including overall survival (OS), disease-free survival (DFS), and recurrence rate (RR) among the three groups. Groups 1, 2, and 3 involved 75, 56, and 43 patients, respectively. Postoperative morbidity rates were 17.3%, 10.8%, and 9.3% in Groups 1, 2, and 3, respectively (P = 0.337). RRs were 16.0%, 35.7%, and 30.2% in Groups 1, 2, and 3, respectively (P = 0.029). In multivariate analysis, the time interval for BTS was an independent risk factor for DFS (P < 0.001; HR, 14.463; 95% CI, 1.458–3.255) and OS (P = 0.027; HR, 4.917; 95% CI, 1.071–3.059). In conclusion, the perioperative short-term outcome was not affected by the time interval of BTS. However, elective surgery within 7 days after colonic stent might be suggested to balance the short-term benefits and long-term oncologic risks. |
format | Online Article Text |
id | pubmed-7289825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72898252020-06-15 The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer Kye, Bong-Hyeon Kim, Ji-Hoon Kim, Hyung-Jin Lee, Yoon Suk Lee, In-Kyu Kang, Won Kyung Cho, Hyeon-Min Ahn, Chang-Hyeok Oh, Seong-Taek Sci Rep Article A bridge to surgery (BTS) after a colonic stent for obstructive colon cancer has not been accepted as a standard treatment strategy. Also, there is no consensus regarding the optimal time interval for BTS. We aimed to identify the optimal timing for BTS after stent placement to decrease the oncologic risk. We retrospectively collected data of 174 patients who underwent BTS after stent placement for stage II or III obstructive colon cancer from five hospitals. We divided the patients into three groups based on the time interval for BTS after stent placement: within 7 days (Group 1), from 8 to 14 days (Group 2), and after 14 days (Group 3). The primary outcome was to compare the oncologic outcomes including overall survival (OS), disease-free survival (DFS), and recurrence rate (RR) among the three groups. Groups 1, 2, and 3 involved 75, 56, and 43 patients, respectively. Postoperative morbidity rates were 17.3%, 10.8%, and 9.3% in Groups 1, 2, and 3, respectively (P = 0.337). RRs were 16.0%, 35.7%, and 30.2% in Groups 1, 2, and 3, respectively (P = 0.029). In multivariate analysis, the time interval for BTS was an independent risk factor for DFS (P < 0.001; HR, 14.463; 95% CI, 1.458–3.255) and OS (P = 0.027; HR, 4.917; 95% CI, 1.071–3.059). In conclusion, the perioperative short-term outcome was not affected by the time interval of BTS. However, elective surgery within 7 days after colonic stent might be suggested to balance the short-term benefits and long-term oncologic risks. Nature Publishing Group UK 2020-06-11 /pmc/articles/PMC7289825/ /pubmed/32528099 http://dx.doi.org/10.1038/s41598-020-66508-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kye, Bong-Hyeon Kim, Ji-Hoon Kim, Hyung-Jin Lee, Yoon Suk Lee, In-Kyu Kang, Won Kyung Cho, Hyeon-Min Ahn, Chang-Hyeok Oh, Seong-Taek The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title | The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title_full | The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title_fullStr | The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title_full_unstemmed | The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title_short | The optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
title_sort | optimal time interval between the placement of self-expandable metallic stent and elective surgery in patients with obstructive colon cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289825/ https://www.ncbi.nlm.nih.gov/pubmed/32528099 http://dx.doi.org/10.1038/s41598-020-66508-6 |
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