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A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China

To discuss combinations of traditional screening and noninvasive prenatal screening (NIPS) and to compare which traditional screening is the most suitable first-line screening approach to NIPS, pregnant women were recruited in this retrospective observational study. Pregnant women underwent one of f...

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Autores principales: Luo, Wei, He, Bin, Han, Daiwen, Yuan, Lixing, Chen, Xinlian, Pang, Ling, Tang, Jun, Zou, Fene, Zhao, Kai, Du, Yepei, Liu, Hongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289849/
https://www.ncbi.nlm.nih.gov/pubmed/32528157
http://dx.doi.org/10.1038/s41598-020-66320-2
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author Luo, Wei
He, Bin
Han, Daiwen
Yuan, Lixing
Chen, Xinlian
Pang, Ling
Tang, Jun
Zou, Fene
Zhao, Kai
Du, Yepei
Liu, Hongqian
author_facet Luo, Wei
He, Bin
Han, Daiwen
Yuan, Lixing
Chen, Xinlian
Pang, Ling
Tang, Jun
Zou, Fene
Zhao, Kai
Du, Yepei
Liu, Hongqian
author_sort Luo, Wei
collection PubMed
description To discuss combinations of traditional screening and noninvasive prenatal screening (NIPS) and to compare which traditional screening is the most suitable first-line screening approach to NIPS, pregnant women were recruited in this retrospective observational study. Pregnant women underwent one of four traditional screening tests. The 9 contingent models were combined by high risk cut-offs of 1:50, 1:100, 1:270 and intermediate risk cut-offs of 1:1000, 1:1500, 1:2000. We analyzed cost and performance of various screening models with contingent screening of different risk cut-offs. Compared with other screening tests, combined first-trimester screening (CFTS) had the lowest proportion of high risk (≥1:270) with the highest detection rate (DR) (78.79%) and the lowest proportion of intermediate risk (1:271~1:1000). When intermediate risk was 1:51 ~1:1500, CFTS as first-line screening had the lowest cost with DR of 93.94%. Other screening tests as the first-line screening with intermediate risk of 1:51~1:1000 had the lowest cost, there DR were 90.91%, 84.62%, 91.67%, respectively. Our study demonstrated if only one traditional screening was allowed to screen pregnant women, CFTS was recommended as the first choice. According to local health and economic conditions, adopting appropriate traditional screening with suitable cut-offs as first-line screening will contributed to a cost-effective screening model.
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spelling pubmed-72898492020-06-15 A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China Luo, Wei He, Bin Han, Daiwen Yuan, Lixing Chen, Xinlian Pang, Ling Tang, Jun Zou, Fene Zhao, Kai Du, Yepei Liu, Hongqian Sci Rep Article To discuss combinations of traditional screening and noninvasive prenatal screening (NIPS) and to compare which traditional screening is the most suitable first-line screening approach to NIPS, pregnant women were recruited in this retrospective observational study. Pregnant women underwent one of four traditional screening tests. The 9 contingent models were combined by high risk cut-offs of 1:50, 1:100, 1:270 and intermediate risk cut-offs of 1:1000, 1:1500, 1:2000. We analyzed cost and performance of various screening models with contingent screening of different risk cut-offs. Compared with other screening tests, combined first-trimester screening (CFTS) had the lowest proportion of high risk (≥1:270) with the highest detection rate (DR) (78.79%) and the lowest proportion of intermediate risk (1:271~1:1000). When intermediate risk was 1:51 ~1:1500, CFTS as first-line screening had the lowest cost with DR of 93.94%. Other screening tests as the first-line screening with intermediate risk of 1:51~1:1000 had the lowest cost, there DR were 90.91%, 84.62%, 91.67%, respectively. Our study demonstrated if only one traditional screening was allowed to screen pregnant women, CFTS was recommended as the first choice. According to local health and economic conditions, adopting appropriate traditional screening with suitable cut-offs as first-line screening will contributed to a cost-effective screening model. Nature Publishing Group UK 2020-06-11 /pmc/articles/PMC7289849/ /pubmed/32528157 http://dx.doi.org/10.1038/s41598-020-66320-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Luo, Wei
He, Bin
Han, Daiwen
Yuan, Lixing
Chen, Xinlian
Pang, Ling
Tang, Jun
Zou, Fene
Zhao, Kai
Du, Yepei
Liu, Hongqian
A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title_full A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title_fullStr A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title_full_unstemmed A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title_short A Retrospective Analysis Of Different Contingent Screening Models For Fetal Down Syndrome In Southwestern China
title_sort retrospective analysis of different contingent screening models for fetal down syndrome in southwestern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289849/
https://www.ncbi.nlm.nih.gov/pubmed/32528157
http://dx.doi.org/10.1038/s41598-020-66320-2
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