Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice

Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background—SJL/J mice. The absence of TRP53 (TRP53 nullizygosity) leads to a shift in the tumor spectrum from a non...

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Detalles Bibliográficos
Autores principales: Branca, Jane A, Low, Benjamin E, Saxl, Ruth L, Sargent, Jennifer K, Doty, Rosalinda A, Wiles, Michael V, Dumont, Beth L, Hasham, Muneer G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289902/
https://www.ncbi.nlm.nih.gov/pubmed/32577159
http://dx.doi.org/10.18632/genesandcancer.198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289902/
https://www.ncbi.nlm.nih.gov/pubmed/32577159
http://dx.doi.org/10.18632/genesandcancer.198

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