Cargando…

Non-circadian aspects of BHLHE40 cellular function in cancer

While many genes specifically act as oncogenes or tumor suppressors, others are tumor promoters or suppressors in a context-dependent manner. Here we will review the basic-helix-loop-helix (BHLH) protein BHLHE40, (also known as BHLHB2, STRA13, DEC1, or SHARP2) which is overexpressed in gastric, brea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kiss, Zsofia, Mudryj, Maria, Ghosh, Paramita M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289903/ https://www.ncbi.nlm.nih.gov/pubmed/32577154 http://dx.doi.org/10.18632/genesandcancer.201

Ejemplares similares

Bhlhe40: Gatekeeper of the GC
por: Nutt, Stephen L., et al.
Publicado: (2021)

Beyond Prostate Cancer: An Androgen Receptor Splice Variant Expression in Multiple Malignancies, Non-Cancer Pathologies, and Development
por: Katleba, Kimberley D., et al.
Publicado: (2023)

Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells
por: Chang, Hsuan Chia, et al.
Publicado: (2018)

Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
por: Furukawa, Tatsuhiko, et al.
Publicado: (2023)

Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
por: Gabryšová, Leona, et al.
Publicado: (2018)

Bhlhe40 function in activated B and T(FH) cells restrains the GC reaction and prevents lymphomagenesis
por: Rauschmeier, René, et al.
Publicado: (2021)

Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells
por: Asanoma, Kazuo, et al.
Publicado: (2019)

Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation
por: Lin, Chih-Chung, et al.
Publicado: (2014)

Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40
por: Yin, Yongmei, et al.
Publicado: (2023)

Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism
por: Mudryj, Maria, et al.
Publicado: (2023)

Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7
por: Sui, Yuan, et al.
Publicado: (2023)

BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
por: Salmon, Avery J., et al.
Publicado: (2022)

Upregulation of INHBA mediated by the transcription factor BHLHE40 promotes colon cancer cell proliferation and migration
por: Wang, Jianan, et al.
Publicado: (2022)

Comparative Cancer Cell Signaling in Muscle-Invasive Urothelial Carcinoma of the Bladder in Dogs and Humans
por: Tsamouri, Maria Malvina, et al.
Publicado: (2021)

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity
por: Jarjour, Nicholas N., et al.
Publicado: (2019)

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
por: Zhang, Yufeng, et al.
Publicado: (2022)

The role of BHLHE40 in clinical features and prognosis value of PDAC by comprehensive analysis and in vitro validation
por: Liu, Chao, et al.
Publicado: (2023)

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies
por: Lucchesi, Christopher A., et al.
Publicado: (2023)

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion
por: Sethuraman, Aarti, et al.
Publicado: (2018)

IL-1–induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation
por: Lin, Chih-Chung, et al.
Publicado: (2016)

MiR-494-3p Upregulation Exacerbates Cerebral Ischemia Injury by Targeting Bhlhe40
por: Sun, Lingjiang, et al.
Publicado: (2022)

BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
por: Mercado, Miguel A. B., et al.
Publicado: (2023)

Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus
por: Hamilton, Kelly A., et al.
Publicado: (2018)

The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination
por: Yu, Fang, et al.
Publicado: (2018)

Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice
por: Ren, Kai-Wen, et al.
Publicado: (2022)

Involvement of a Basic Helix-Loop-Helix Gene BHLHE40 in Specification of Chicken Retinal Pigment Epithelium
por: Kinuhata, Toshiki, et al.
Publicado: (2022)

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40
por: Wu, Jennifer E., et al.
Publicado: (2023)

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy
por: Messner, Elisabeth A., et al.
Publicado: (2020)

Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma
por: Kunadirek, Pattapon, et al.
Publicado: (2021)

17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression
por: Feng, Dan-dan, et al.
Publicado: (2021)

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues
por: Podlesny-Drabiniok, Anna, et al.
Publicado: (2023)

BHLHE40 Mediates Cross-Talk between Pathogenic T(H)17 Cells and Myeloid Cells during Experimental Autoimmune Encephalomyelitis
por: Cook, Melissa E., et al.
Publicado: (2023)

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver
por: Tian, Jing, et al.
Publicado: (2018)

Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta
por: Zhao, Lu, et al.
Publicado: (2021)

BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation
por: Uyeda, Molly Javier, et al.
Publicado: (2021)

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
por: Bigot, Pierre, et al.
Publicado: (2016)

Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions
por: Hu, Gongcheng, et al.
Publicado: (2020)

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment
por: Wang, Liwen, et al.
Publicado: (2023)

High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study
por: Xu, Hui, et al.
Publicado: (2023)

BHLHE40 Maintains the Stemness of PαS Cells In Vitro by Targeting Zbp1 through the Wnt/β-Catenin Signaling Pathway
por: Hu, Menglong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pkc6sn2aj4mr3qhb1ecr7a33ca