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The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells
Acute myeloid leukemia (AML) is a progressive hematopoietic-derived cancer arising from stepwise genetic mutations of the myeloid lineage. cAMP response element-binding protein (CREB) is a nuclear transcription factor, which plays a key role in the multistep process of leukemogenesis, thus emerging...
Autores principales: | Illiano, Michela, Conte, Mariarosaria, Salzillo, Alessia, Ragone, Angela, Spina, Annamaria, Nebbioso, Angela, Altucci, Lucia, Sapio, Luigi, Naviglio, Silvio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289982/ https://www.ncbi.nlm.nih.gov/pubmed/32582541 http://dx.doi.org/10.3389/fonc.2020.00799 |
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