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Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease

Aging is the major risk factor of the most common (∼95% of cases) sporadic Alzheimer’s disease (AD). Accumulating data indicate middle age as a critical period for the relevant pathological processes, however, the question of when AD starts to develop remains open. It has been reported only recently...

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Autores principales: Rudnitskaya, Ekaterina A., Kozlova, Tatiana A., Burnyasheva, Alena O., Tarasova, Anna E., Pankova, Tatiana M., Starostina, Marina V., Stefanova, Natalia A., Kolosova, Nataliya G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289999/
https://www.ncbi.nlm.nih.gov/pubmed/32581685
http://dx.doi.org/10.3389/fnins.2020.00533
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author Rudnitskaya, Ekaterina A.
Kozlova, Tatiana A.
Burnyasheva, Alena O.
Tarasova, Anna E.
Pankova, Tatiana M.
Starostina, Marina V.
Stefanova, Natalia A.
Kolosova, Nataliya G.
author_facet Rudnitskaya, Ekaterina A.
Kozlova, Tatiana A.
Burnyasheva, Alena O.
Tarasova, Anna E.
Pankova, Tatiana M.
Starostina, Marina V.
Stefanova, Natalia A.
Kolosova, Nataliya G.
author_sort Rudnitskaya, Ekaterina A.
collection PubMed
description Aging is the major risk factor of the most common (∼95% of cases) sporadic Alzheimer’s disease (AD). Accumulating data indicate middle age as a critical period for the relevant pathological processes, however, the question of when AD starts to develop remains open. It has been reported only recently that in the early postnatal period—when brain development is completing—preconditions for a decrease in cognitive abilities and for accelerated aging can form. Here, we hypothesized that specific features of early postnatal brain development may be considered some of the prerequisites of AD development at an advanced age. To test this hypothesis, we used OXYS rats, which are a suitable model of sporadic AD. The duration of gestation, litter size, and weight at birth were lower in OXYS rats compared to control Wistar rats. The shortened duration of gestation may result in developmental retardation. Indeed, we noted decreased locomotor activity and increased anxiety in OXYS rats already at a young age: possible signs of altered brain development. We demonstrated retardation of the peak of postnatal neurogenesis in the hippocampal dentate gyrus of OXYS rats. Delayed neuronal maturation led to alterations of mossy-fiber formation: a shortened suprapyramidal bundle and longer infrapyramidal bundle, less pronounced fasciculation of granule cells’ axons, and smaller size and irregular shape of nuclei in the CA3 pyramidal layer. These changes were accompanied by altered astrocytic migration. The observed features of early development may be considered some of the risk factors of the AD-like pathology that manifests itself in OXYS rats late in life.
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spelling pubmed-72899992020-06-23 Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease Rudnitskaya, Ekaterina A. Kozlova, Tatiana A. Burnyasheva, Alena O. Tarasova, Anna E. Pankova, Tatiana M. Starostina, Marina V. Stefanova, Natalia A. Kolosova, Nataliya G. Front Neurosci Neuroscience Aging is the major risk factor of the most common (∼95% of cases) sporadic Alzheimer’s disease (AD). Accumulating data indicate middle age as a critical period for the relevant pathological processes, however, the question of when AD starts to develop remains open. It has been reported only recently that in the early postnatal period—when brain development is completing—preconditions for a decrease in cognitive abilities and for accelerated aging can form. Here, we hypothesized that specific features of early postnatal brain development may be considered some of the prerequisites of AD development at an advanced age. To test this hypothesis, we used OXYS rats, which are a suitable model of sporadic AD. The duration of gestation, litter size, and weight at birth were lower in OXYS rats compared to control Wistar rats. The shortened duration of gestation may result in developmental retardation. Indeed, we noted decreased locomotor activity and increased anxiety in OXYS rats already at a young age: possible signs of altered brain development. We demonstrated retardation of the peak of postnatal neurogenesis in the hippocampal dentate gyrus of OXYS rats. Delayed neuronal maturation led to alterations of mossy-fiber formation: a shortened suprapyramidal bundle and longer infrapyramidal bundle, less pronounced fasciculation of granule cells’ axons, and smaller size and irregular shape of nuclei in the CA3 pyramidal layer. These changes were accompanied by altered astrocytic migration. The observed features of early development may be considered some of the risk factors of the AD-like pathology that manifests itself in OXYS rats late in life. Frontiers Media S.A. 2020-06-05 /pmc/articles/PMC7289999/ /pubmed/32581685 http://dx.doi.org/10.3389/fnins.2020.00533 Text en Copyright © 2020 Rudnitskaya, Kozlova, Burnyasheva, Tarasova, Pankova, Starostina, Stefanova and Kolosova. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rudnitskaya, Ekaterina A.
Kozlova, Tatiana A.
Burnyasheva, Alena O.
Tarasova, Anna E.
Pankova, Tatiana M.
Starostina, Marina V.
Stefanova, Natalia A.
Kolosova, Nataliya G.
Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title_full Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title_fullStr Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title_full_unstemmed Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title_short Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer’s Disease
title_sort features of postnatal hippocampal development in a rat model of sporadic alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289999/
https://www.ncbi.nlm.nih.gov/pubmed/32581685
http://dx.doi.org/10.3389/fnins.2020.00533
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