MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially i...

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Detalles Bibliográficos
Autores principales: Huang, Jen-Wei, Acharya, Ananya, Taglialatela, Angelo, Nambiar, Tarun S., Cuella-Martin, Raquel, Leuzzi, Giuseppe, Hayward, Samuel B., Joseph, Sarah A., Brunette, Gregory J., Anand, Roopesh, Soni, Rajesh K., Clark, Nathan L., Bernstein, Kara A., Cejka, Petr, Ciccia, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290032/
https://www.ncbi.nlm.nih.gov/pubmed/32528060
http://dx.doi.org/10.1038/s41467-020-16718-3

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