Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection

Alloantigen presentation is an essential process in acute allorejection. In this context, we speculated on a pathogenic role of cathepsin S (Cat-S), a cysteine protease known to promote antigenic peptide loading into MHC class II and to activate protease-activated receptor (PAR)-2 on intrarenal micr...

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Detalles Bibliográficos
Autores principales: Lei, Yutian, Ehle, Benjamin, Kumar, Santhosh V., Müller, Susanne, Moll, Solange, Malone, Andrew F., Humphreys, Benjamin D., Andrassy, Joachim, Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290053/
https://www.ncbi.nlm.nih.gov/pubmed/32582696
http://dx.doi.org/10.3389/fcell.2020.00398

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