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Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea

This prospective study compared exercise test and intravenous fluid challenge in a single right heart catheter procedure to detect latent diastolic heart failure in patients with echocardiographic heart failure with preserved ejection function. We included 49 patients (73% female) with heart failure...

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Autores principales: Ewert, Ralf, Heine, Alexander, Müller-Heinrich, Annegret, Bollmann, Tom, Obst, Anne, Desole, Susanna, Knaak, Christine, Stubbe, Beate, Opitz, Christian F., Habedank, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290273/
https://www.ncbi.nlm.nih.gov/pubmed/32577217
http://dx.doi.org/10.1177/2045894020917887
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author Ewert, Ralf
Heine, Alexander
Müller-Heinrich, Annegret
Bollmann, Tom
Obst, Anne
Desole, Susanna
Knaak, Christine
Stubbe, Beate
Opitz, Christian F.
Habedank, Dirk
author_facet Ewert, Ralf
Heine, Alexander
Müller-Heinrich, Annegret
Bollmann, Tom
Obst, Anne
Desole, Susanna
Knaak, Christine
Stubbe, Beate
Opitz, Christian F.
Habedank, Dirk
author_sort Ewert, Ralf
collection PubMed
description This prospective study compared exercise test and intravenous fluid challenge in a single right heart catheter procedure to detect latent diastolic heart failure in patients with echocardiographic heart failure with preserved ejection function. We included 49 patients (73% female) with heart failure with preserved ejection function and pulmonary artery wedge pressure ≤15 mmHg. A subgroup of 26 patients had precapillary pulmonary hypertension. Invasive haemodynamic and gas exchange parameters were measured at rest, 45° upright position, during exercise, after complete haemodynamic and respiratory recovery in lying position, and after rapid infusion of 500 mL isotonic solution. Most haemodynamic parameters increased at both exercise and intravenous fluid challenge, with the higher increase at exercise. Pulmonary vascular resistance decreased by –0.21 wood units at exercise and –0.56 wood units at intravenous fluid challenge (p = 0.3); 20% (10 of 49) of patients had an increase in pulmonary artery wedge pressure above the upper limit of 20 mmHg at exercise, and 20% above the respective limit of 18 mmHg after intravenous fluid challenge. However, only three patients exceeded the upper limit of pulmonary artery wedge pressure in both tests, i.e. seven patients only at exercise and seven other patients only after intravenous fluid challenge. In the subgroup of pulmonary hypertension patients, only two patients exceeded pulmonary artery wedge pressure limits in both tests, further five patients at exercise and four patients after intravenous fluid challenge. A sequential protocol in the same patient showed a significantly higher increase in haemodynamic parameters at exercise compared to intravenous fluid challenge. Both methods can unmask diastolic dysfunction at right heart catheter procedure, but in different patient groups.
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spelling pubmed-72902732020-06-22 Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea Ewert, Ralf Heine, Alexander Müller-Heinrich, Annegret Bollmann, Tom Obst, Anne Desole, Susanna Knaak, Christine Stubbe, Beate Opitz, Christian F. Habedank, Dirk Pulm Circ Research Article This prospective study compared exercise test and intravenous fluid challenge in a single right heart catheter procedure to detect latent diastolic heart failure in patients with echocardiographic heart failure with preserved ejection function. We included 49 patients (73% female) with heart failure with preserved ejection function and pulmonary artery wedge pressure ≤15 mmHg. A subgroup of 26 patients had precapillary pulmonary hypertension. Invasive haemodynamic and gas exchange parameters were measured at rest, 45° upright position, during exercise, after complete haemodynamic and respiratory recovery in lying position, and after rapid infusion of 500 mL isotonic solution. Most haemodynamic parameters increased at both exercise and intravenous fluid challenge, with the higher increase at exercise. Pulmonary vascular resistance decreased by –0.21 wood units at exercise and –0.56 wood units at intravenous fluid challenge (p = 0.3); 20% (10 of 49) of patients had an increase in pulmonary artery wedge pressure above the upper limit of 20 mmHg at exercise, and 20% above the respective limit of 18 mmHg after intravenous fluid challenge. However, only three patients exceeded the upper limit of pulmonary artery wedge pressure in both tests, i.e. seven patients only at exercise and seven other patients only after intravenous fluid challenge. In the subgroup of pulmonary hypertension patients, only two patients exceeded pulmonary artery wedge pressure limits in both tests, further five patients at exercise and four patients after intravenous fluid challenge. A sequential protocol in the same patient showed a significantly higher increase in haemodynamic parameters at exercise compared to intravenous fluid challenge. Both methods can unmask diastolic dysfunction at right heart catheter procedure, but in different patient groups. SAGE Publications 2020-06-11 /pmc/articles/PMC7290273/ /pubmed/32577217 http://dx.doi.org/10.1177/2045894020917887 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Ewert, Ralf
Heine, Alexander
Müller-Heinrich, Annegret
Bollmann, Tom
Obst, Anne
Desole, Susanna
Knaak, Christine
Stubbe, Beate
Opitz, Christian F.
Habedank, Dirk
Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title_full Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title_fullStr Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title_full_unstemmed Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title_short Exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
title_sort exercise and fluid challenge during right heart catheterisation for evaluation of dyspnoea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290273/
https://www.ncbi.nlm.nih.gov/pubmed/32577217
http://dx.doi.org/10.1177/2045894020917887
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