A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is, however, not expressed in systemic tissues,...

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Detalles Bibliográficos
Autores principales: Solanki, Ashish K., Kondkar, Altaf A., Fogerty, Joseph, Su, Yanhui, Kim, Seok-Hyung, Lipschutz, Joshua H., Nihalani, Deepak, Perkins, Brian D., Lobo, Glenn P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290320/
https://www.ncbi.nlm.nih.gov/pubmed/32365517
http://dx.doi.org/10.3390/cells9051099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290320/
https://www.ncbi.nlm.nih.gov/pubmed/32365517
http://dx.doi.org/10.3390/cells9051099

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