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Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study

Postoperative delirium is a common complication after liver transplantation (LT). A high model for end-stage liver disease (MELD) score is an independent risk factor for postoperative delirium, but it is unclear which of the components of this score are risk indicators. The aim of this study was to...

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Autores principales: Park, Kyu Hee, Son, Hyo Jung, Choi, Yoon Ji, Park, Gene Hyun, Lee, Yoon Sook, Park, Ju Yeon, Ri, Hyun-Su, Shim, Jae Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290386/
https://www.ncbi.nlm.nih.gov/pubmed/32456289
http://dx.doi.org/10.3390/jcm9051591
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author Park, Kyu Hee
Son, Hyo Jung
Choi, Yoon Ji
Park, Gene Hyun
Lee, Yoon Sook
Park, Ju Yeon
Ri, Hyun-Su
Shim, Jae Ryong
author_facet Park, Kyu Hee
Son, Hyo Jung
Choi, Yoon Ji
Park, Gene Hyun
Lee, Yoon Sook
Park, Ju Yeon
Ri, Hyun-Su
Shim, Jae Ryong
author_sort Park, Kyu Hee
collection PubMed
description Postoperative delirium is a common complication after liver transplantation (LT). A high model for end-stage liver disease (MELD) score is an independent risk factor for postoperative delirium, but it is unclear which of the components of this score are risk indicators. The aim of this study was to analyze the incidence of postoperative delirium according to the preoperative serum bilirubin level, a component of the MELD score, in patients who underwent LT. The medical records of 325 patients who underwent LT from January 2010 to February 2019 at a single university hospital were retrospectively reviewed. The patients were divided into two groups: those who experienced postoperative delirium (Delirium group, n = 69) and those who did not (Control group, n = 256). Data on the patients’ demographic characteristics, perioperative management, and postoperative complications were collected. Mean preoperative bilirubin level was higher in the Delirium group than in the Control group (p < 0.0001). In the Delirium group, 54 (78.26%) patients had preoperative bilirubin levels above 3.5 mg/dL. In the multivariate analysis, preoperative bilirubin above 3.5 mg/dL was associated with postoperative delirium (p = 0.002). Therefore, preoperative hyperbilirubinemia is an independent risk factor for postoperative delirium.
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spelling pubmed-72903862020-06-15 Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study Park, Kyu Hee Son, Hyo Jung Choi, Yoon Ji Park, Gene Hyun Lee, Yoon Sook Park, Ju Yeon Ri, Hyun-Su Shim, Jae Ryong J Clin Med Article Postoperative delirium is a common complication after liver transplantation (LT). A high model for end-stage liver disease (MELD) score is an independent risk factor for postoperative delirium, but it is unclear which of the components of this score are risk indicators. The aim of this study was to analyze the incidence of postoperative delirium according to the preoperative serum bilirubin level, a component of the MELD score, in patients who underwent LT. The medical records of 325 patients who underwent LT from January 2010 to February 2019 at a single university hospital were retrospectively reviewed. The patients were divided into two groups: those who experienced postoperative delirium (Delirium group, n = 69) and those who did not (Control group, n = 256). Data on the patients’ demographic characteristics, perioperative management, and postoperative complications were collected. Mean preoperative bilirubin level was higher in the Delirium group than in the Control group (p < 0.0001). In the Delirium group, 54 (78.26%) patients had preoperative bilirubin levels above 3.5 mg/dL. In the multivariate analysis, preoperative bilirubin above 3.5 mg/dL was associated with postoperative delirium (p = 0.002). Therefore, preoperative hyperbilirubinemia is an independent risk factor for postoperative delirium. MDPI 2020-05-24 /pmc/articles/PMC7290386/ /pubmed/32456289 http://dx.doi.org/10.3390/jcm9051591 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Kyu Hee
Son, Hyo Jung
Choi, Yoon Ji
Park, Gene Hyun
Lee, Yoon Sook
Park, Ju Yeon
Ri, Hyun-Su
Shim, Jae Ryong
Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title_full Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title_fullStr Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title_full_unstemmed Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title_short Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study
title_sort liver transplant patients with high preoperative serum bilirubin levels are at increased risk of postoperative delirium: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290386/
https://www.ncbi.nlm.nih.gov/pubmed/32456289
http://dx.doi.org/10.3390/jcm9051591
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