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Neutrophil Phenotypes in Coronary Artery Disease

Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (U...

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Autores principales: Maréchal, Patrick, Tridetti, Julien, Nguyen, Mai-Linh, Wéra, Odile, Jiang, Zheshen, Gustin, Maxime, Donneau, Anne-Françoise, Oury, Cécile, Lancellotti, Patrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290445/
https://www.ncbi.nlm.nih.gov/pubmed/32466264
http://dx.doi.org/10.3390/jcm9051602
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author Maréchal, Patrick
Tridetti, Julien
Nguyen, Mai-Linh
Wéra, Odile
Jiang, Zheshen
Gustin, Maxime
Donneau, Anne-Françoise
Oury, Cécile
Lancellotti, Patrizio
author_facet Maréchal, Patrick
Tridetti, Julien
Nguyen, Mai-Linh
Wéra, Odile
Jiang, Zheshen
Gustin, Maxime
Donneau, Anne-Françoise
Oury, Cécile
Lancellotti, Patrizio
author_sort Maréchal, Patrick
collection PubMed
description Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (UA) (n = 19), Non-ST-Elevation Myocardial Infarction (NSTEMI) (n = 25), and ST-Elevation Myocardial Infarction (STEMI) (n = 27). At the time of inclusion, blood neutrophil subpopulations were analysed by flow cytometry. Differential blood cell count and plasma levels of neutrophilic soluble markers were recorded at admission and, for half of patients, at six-month follow-up. STEMI and NSTEMI patients displayed higher neutrophil count and neutrophil-to-lymphocyte ratio than stable and UA patients (p < 0.0001), which normalized at six-month post-MI. Atypical low-density neutrophils were detected in the blood of the four patient groups. STEMI patients were characterized by elevated percentages of band cells compared to the other patients (p = 0.019). Multivariable logistic regression analysis revealed that plasma levels of total myeloperoxidase was associated with STEMI compared to stable (OR: 1.434; 95% CI: 1.119–1.837; P < 0.0001), UA (1.47; 1.146–1.886; p = 0.002), and NSTEMI (1.213; 1.1–1.134; p = 0.0001) patients, while increased neutrophil side scatter (SSC) signal intensity was associated with NSTEMI compared to stable patients (3.828; 1.033–14.184; p = 0.045). Hence, changes in neutrophil phenotype are concomitant to ACS.
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spelling pubmed-72904452020-06-15 Neutrophil Phenotypes in Coronary Artery Disease Maréchal, Patrick Tridetti, Julien Nguyen, Mai-Linh Wéra, Odile Jiang, Zheshen Gustin, Maxime Donneau, Anne-Françoise Oury, Cécile Lancellotti, Patrizio J Clin Med Article Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (UA) (n = 19), Non-ST-Elevation Myocardial Infarction (NSTEMI) (n = 25), and ST-Elevation Myocardial Infarction (STEMI) (n = 27). At the time of inclusion, blood neutrophil subpopulations were analysed by flow cytometry. Differential blood cell count and plasma levels of neutrophilic soluble markers were recorded at admission and, for half of patients, at six-month follow-up. STEMI and NSTEMI patients displayed higher neutrophil count and neutrophil-to-lymphocyte ratio than stable and UA patients (p < 0.0001), which normalized at six-month post-MI. Atypical low-density neutrophils were detected in the blood of the four patient groups. STEMI patients were characterized by elevated percentages of band cells compared to the other patients (p = 0.019). Multivariable logistic regression analysis revealed that plasma levels of total myeloperoxidase was associated with STEMI compared to stable (OR: 1.434; 95% CI: 1.119–1.837; P < 0.0001), UA (1.47; 1.146–1.886; p = 0.002), and NSTEMI (1.213; 1.1–1.134; p = 0.0001) patients, while increased neutrophil side scatter (SSC) signal intensity was associated with NSTEMI compared to stable patients (3.828; 1.033–14.184; p = 0.045). Hence, changes in neutrophil phenotype are concomitant to ACS. MDPI 2020-05-25 /pmc/articles/PMC7290445/ /pubmed/32466264 http://dx.doi.org/10.3390/jcm9051602 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maréchal, Patrick
Tridetti, Julien
Nguyen, Mai-Linh
Wéra, Odile
Jiang, Zheshen
Gustin, Maxime
Donneau, Anne-Françoise
Oury, Cécile
Lancellotti, Patrizio
Neutrophil Phenotypes in Coronary Artery Disease
title Neutrophil Phenotypes in Coronary Artery Disease
title_full Neutrophil Phenotypes in Coronary Artery Disease
title_fullStr Neutrophil Phenotypes in Coronary Artery Disease
title_full_unstemmed Neutrophil Phenotypes in Coronary Artery Disease
title_short Neutrophil Phenotypes in Coronary Artery Disease
title_sort neutrophil phenotypes in coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290445/
https://www.ncbi.nlm.nih.gov/pubmed/32466264
http://dx.doi.org/10.3390/jcm9051602
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