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Neutrophil Phenotypes in Coronary Artery Disease
Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (U...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290445/ https://www.ncbi.nlm.nih.gov/pubmed/32466264 http://dx.doi.org/10.3390/jcm9051602 |
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author | Maréchal, Patrick Tridetti, Julien Nguyen, Mai-Linh Wéra, Odile Jiang, Zheshen Gustin, Maxime Donneau, Anne-Françoise Oury, Cécile Lancellotti, Patrizio |
author_facet | Maréchal, Patrick Tridetti, Julien Nguyen, Mai-Linh Wéra, Odile Jiang, Zheshen Gustin, Maxime Donneau, Anne-Françoise Oury, Cécile Lancellotti, Patrizio |
author_sort | Maréchal, Patrick |
collection | PubMed |
description | Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (UA) (n = 19), Non-ST-Elevation Myocardial Infarction (NSTEMI) (n = 25), and ST-Elevation Myocardial Infarction (STEMI) (n = 27). At the time of inclusion, blood neutrophil subpopulations were analysed by flow cytometry. Differential blood cell count and plasma levels of neutrophilic soluble markers were recorded at admission and, for half of patients, at six-month follow-up. STEMI and NSTEMI patients displayed higher neutrophil count and neutrophil-to-lymphocyte ratio than stable and UA patients (p < 0.0001), which normalized at six-month post-MI. Atypical low-density neutrophils were detected in the blood of the four patient groups. STEMI patients were characterized by elevated percentages of band cells compared to the other patients (p = 0.019). Multivariable logistic regression analysis revealed that plasma levels of total myeloperoxidase was associated with STEMI compared to stable (OR: 1.434; 95% CI: 1.119–1.837; P < 0.0001), UA (1.47; 1.146–1.886; p = 0.002), and NSTEMI (1.213; 1.1–1.134; p = 0.0001) patients, while increased neutrophil side scatter (SSC) signal intensity was associated with NSTEMI compared to stable patients (3.828; 1.033–14.184; p = 0.045). Hence, changes in neutrophil phenotype are concomitant to ACS. |
format | Online Article Text |
id | pubmed-7290445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72904452020-06-15 Neutrophil Phenotypes in Coronary Artery Disease Maréchal, Patrick Tridetti, Julien Nguyen, Mai-Linh Wéra, Odile Jiang, Zheshen Gustin, Maxime Donneau, Anne-Françoise Oury, Cécile Lancellotti, Patrizio J Clin Med Article Clinical evidence indicates that innate immune cells may contribute to acute coronary syndrome (ACS). Our prospective study aimed at investigating the association of neutrophil phenotypes with ACS. 108 patients were categorized into chronic stable coronary artery disease (n = 37), unstable angina (UA) (n = 19), Non-ST-Elevation Myocardial Infarction (NSTEMI) (n = 25), and ST-Elevation Myocardial Infarction (STEMI) (n = 27). At the time of inclusion, blood neutrophil subpopulations were analysed by flow cytometry. Differential blood cell count and plasma levels of neutrophilic soluble markers were recorded at admission and, for half of patients, at six-month follow-up. STEMI and NSTEMI patients displayed higher neutrophil count and neutrophil-to-lymphocyte ratio than stable and UA patients (p < 0.0001), which normalized at six-month post-MI. Atypical low-density neutrophils were detected in the blood of the four patient groups. STEMI patients were characterized by elevated percentages of band cells compared to the other patients (p = 0.019). Multivariable logistic regression analysis revealed that plasma levels of total myeloperoxidase was associated with STEMI compared to stable (OR: 1.434; 95% CI: 1.119–1.837; P < 0.0001), UA (1.47; 1.146–1.886; p = 0.002), and NSTEMI (1.213; 1.1–1.134; p = 0.0001) patients, while increased neutrophil side scatter (SSC) signal intensity was associated with NSTEMI compared to stable patients (3.828; 1.033–14.184; p = 0.045). Hence, changes in neutrophil phenotype are concomitant to ACS. MDPI 2020-05-25 /pmc/articles/PMC7290445/ /pubmed/32466264 http://dx.doi.org/10.3390/jcm9051602 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maréchal, Patrick Tridetti, Julien Nguyen, Mai-Linh Wéra, Odile Jiang, Zheshen Gustin, Maxime Donneau, Anne-Françoise Oury, Cécile Lancellotti, Patrizio Neutrophil Phenotypes in Coronary Artery Disease |
title | Neutrophil Phenotypes in Coronary Artery Disease |
title_full | Neutrophil Phenotypes in Coronary Artery Disease |
title_fullStr | Neutrophil Phenotypes in Coronary Artery Disease |
title_full_unstemmed | Neutrophil Phenotypes in Coronary Artery Disease |
title_short | Neutrophil Phenotypes in Coronary Artery Disease |
title_sort | neutrophil phenotypes in coronary artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290445/ https://www.ncbi.nlm.nih.gov/pubmed/32466264 http://dx.doi.org/10.3390/jcm9051602 |
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