Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology

Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10–15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a...

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Autores principales: Gringeri, Enrico, Gambato, Martina, Sapisochin, Gonzalo, Ivanics, Tommy, Lynch, Erica Nicola, Mescoli, Claudia, Burra, Patrizia, Cillo, Umberto, Russo, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290472/
https://www.ncbi.nlm.nih.gov/pubmed/32380750
http://dx.doi.org/10.3390/jcm9051353
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author Gringeri, Enrico
Gambato, Martina
Sapisochin, Gonzalo
Ivanics, Tommy
Lynch, Erica Nicola
Mescoli, Claudia
Burra, Patrizia
Cillo, Umberto
Russo, Francesco Paolo
author_facet Gringeri, Enrico
Gambato, Martina
Sapisochin, Gonzalo
Ivanics, Tommy
Lynch, Erica Nicola
Mescoli, Claudia
Burra, Patrizia
Cillo, Umberto
Russo, Francesco Paolo
author_sort Gringeri, Enrico
collection PubMed
description Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10–15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a radical oncological surgery is obtained, 5-year survival rate are around 20–40%. In unresectable patients, following a specific protocol, liver transplantation (LT) for pCCA showed excellent long-term disease-free survival rates. Fewer data are available for iCCA in LT setting. Nevertheless, patients with very early unresectable iCCA appear to achieve excellent outcomes after LT. This review aims to evaluate existing evidence to define the current role of LT in the management of patients with CCA.
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spelling pubmed-72904722020-06-17 Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology Gringeri, Enrico Gambato, Martina Sapisochin, Gonzalo Ivanics, Tommy Lynch, Erica Nicola Mescoli, Claudia Burra, Patrizia Cillo, Umberto Russo, Francesco Paolo J Clin Med Review Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10–15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a radical oncological surgery is obtained, 5-year survival rate are around 20–40%. In unresectable patients, following a specific protocol, liver transplantation (LT) for pCCA showed excellent long-term disease-free survival rates. Fewer data are available for iCCA in LT setting. Nevertheless, patients with very early unresectable iCCA appear to achieve excellent outcomes after LT. This review aims to evaluate existing evidence to define the current role of LT in the management of patients with CCA. MDPI 2020-05-05 /pmc/articles/PMC7290472/ /pubmed/32380750 http://dx.doi.org/10.3390/jcm9051353 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gringeri, Enrico
Gambato, Martina
Sapisochin, Gonzalo
Ivanics, Tommy
Lynch, Erica Nicola
Mescoli, Claudia
Burra, Patrizia
Cillo, Umberto
Russo, Francesco Paolo
Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title_full Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title_fullStr Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title_full_unstemmed Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title_short Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology
title_sort cholangiocarcinoma as an indication for liver transplantation in the era of transplant oncology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290472/
https://www.ncbi.nlm.nih.gov/pubmed/32380750
http://dx.doi.org/10.3390/jcm9051353
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