Cargando…

Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no curative treatment available. Exploring the genetic and non-genetic contributors to AD pathogenesis is essential to better understand its underlying biological mechanisms, and to develop novel preventive and therapeutic str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nazarian, Alireza, Yashin, Anatoliy I., Kulminski, Alexander M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290473/ https://www.ncbi.nlm.nih.gov/pubmed/32429084 http://dx.doi.org/10.3390/jcm9051489

Ejemplares similares

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
por: Nazarian, Alireza, et al.
Publicado: (2019)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers
por: Nazarian, Alireza, et al.
Publicado: (2021)

EXOME-WIDE STUDY IDENTIFIED 12 PLEIOTROPIC LOCI ASSOCIATED WITH ALZHEIMER’S AND CARDIOVASCULAR DISEASE RISKS
por: Loika, Yury, et al.
Publicado: (2022)

Role of Genetic Interactions in Alzheimer’s Disease: Lessons from Long Life Family Study (LLFS)
por: Yashin, Anatoliy, et al.
Publicado: (2020)

Interaction Analysis Reveals Complex Genetic Associations with Alzheimer’s Disease in the CLU and ABCA7 Gene Regions
por: Nazarian, Alireza, et al.
Publicado: (2023)

Genome‐wide methylomic analyses identify prognostic epigenetic signature in lower grade glioma
por: Guo, Wenna, et al.
Publicado: (2021)

Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder
por: Li, Yongsheng, et al.
Publicado: (2015)

Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives
por: Arbeev, Konstantin G., et al.
Publicado: (2014)

Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival
por: Arbeev, Konstantin G., et al.
Publicado: (2014)

GENETIC ARCHITECTURE OF ALZHEIMER'S DISEASE RISKS
por: Singh, Abanish, et al.
Publicado: (2022)

Genes Involved in Physiological Dysregulation and Decline in Resilience: Role in Alzheimer’s Disease
por: Ukraintseva, Svetlana, et al.
Publicado: (2021)

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Hippocampal Volume Is Smaller In Female Double Carriers Of Two Strongest AD Genetic Risk Factors
por: Ukraintseva, Svetlana, et al.
Publicado: (2021)

Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus
por: Loika, Yury, et al.
Publicado: (2023)

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk
por: Nazarian, Alireza, et al.
Publicado: (2022)

Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution
por: Mendizabal, Isabel, et al.
Publicado: (2016)

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Epigenetic profiling of ADHD symptoms trajectories: A prospective, methylome-wide study
por: Walton, Esther, et al.
Publicado: (2016)

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2016)

Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2018)

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies
por: Kulminski, Alexander M., et al.
Publicado: (2015)

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis
por: Kulminski, Alexander M., et al.
Publicado: (2021)

Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants
por: Ukraintseva, Svetlana, et al.
Publicado: (2015)

Methylome, transcriptome, and PPARγ cistrome analyses reveal two epigenetic transitions in fat cells
por: Takada, Hitomi, et al.
Publicado: (2014)

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer’s Disease and Thirteen Cardiovascular Traits
por: Loika, Yury, et al.
Publicado: (2023)

Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial
por: Engelmann, J., et al.
Publicado: (2022)

Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome
por: Gravina, Silvia, et al.
Publicado: (2016)

Exclusion of Medicare Advantage Enrollees From Medicare Health Outcomes Analyses: Potential for Bias
por: Yashkin, Arseniy, et al.
Publicado: (2020)

Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
por: Arbeev, Konstantin G., et al.
Publicado: (2012)

NEW APPROACH TO STUDYING COLLECTIVE EFFECTS OF GENETIC FACTORS ON ALZHEIMER’S DISEASE
por: Yashin, Anatoliy, et al.
Publicado: (2019)

Genome-Wide Profiling of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Potato Response to DON Stress
por: Shi, Yan, et al.
Publicado: (2022)

GENOME-WIDE META-ANALYSIS SUPPORTS HETEROGENEITY IN POLYGENIC ARCHITECTURE OF DISABILITY
por: Kulminski, Alexander, et al.
Publicado: (2019)

Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age
por: Demetriou, Christiana A., et al.
Publicado: (2013)

High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations
por: Cao, Mingju, et al.
Publicado: (2020)

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease
por: Mano, Tatsuo, et al.
Publicado: (2017)

Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer
por: Li, Yongsheng, et al.
Publicado: (2015)

Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key
por: Yashin, Anatoliy I., et al.
Publicado: (2013)

Using Threshold Regression as an Approach to Incorporate Informative Missingness in Long Life Family Study Data
por: Zhbannikov, Ilya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n4t7ucnrpd4ia7hvkdm0ugjc1c