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D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence

The use of inositols in endocrinological clinical practice is increasingly widespread. Most of the existing evidence concerns myoinositol (MYO), the most abundant form in nature, especially in women with polycystic ovarian syndrome. We have previously shown that MYO increases sperm motility in patie...

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Autores principales: Condorelli, Rosita A., Barbagallo, Federica, Calogero, Aldo E., Cannarella, Rossella, Crafa, Andrea, La Vignera, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290519/
https://www.ncbi.nlm.nih.gov/pubmed/32392776
http://dx.doi.org/10.3390/jcm9051373
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author Condorelli, Rosita A.
Barbagallo, Federica
Calogero, Aldo E.
Cannarella, Rossella
Crafa, Andrea
La Vignera, Sandro
author_facet Condorelli, Rosita A.
Barbagallo, Federica
Calogero, Aldo E.
Cannarella, Rossella
Crafa, Andrea
La Vignera, Sandro
author_sort Condorelli, Rosita A.
collection PubMed
description The use of inositols in endocrinological clinical practice is increasingly widespread. Most of the existing evidence concerns myoinositol (MYO), the most abundant form in nature, especially in women with polycystic ovarian syndrome. We have previously shown that MYO increases sperm motility in patients with asthenozoospermia by the increase of sperm mitochondrial membrane potential (MMP), a biofunctional sperm parameter closely associated to sperm motility. The aim of this study was to evaluate the effects of D-chiro-inositol (DCI), another biologically active isoform of inositols, on sperm MMP, as data on this matter has never been released so far. To accomplish this, semen samples from 15 patients with asthenozoospermia and 15 healthy normozoospermic men were incubated with increasing concentrations of DCI (0, 75, and 750 µg/mL) or phosphate buffer saline for 30 min. Incubation with DCI significantly improved sperm MMP at lower concentrations, and with shorter incubation length than those used in our similar MYO studies. In conclusion, these findings indicate that DCI positively impacts on sperm mitochondrial function in vitro. Studies aimed at assessing the role of DCI in the treatment of asthenozoospermia in-vivo are warranted.
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spelling pubmed-72905192020-06-17 D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence Condorelli, Rosita A. Barbagallo, Federica Calogero, Aldo E. Cannarella, Rossella Crafa, Andrea La Vignera, Sandro J Clin Med Communication The use of inositols in endocrinological clinical practice is increasingly widespread. Most of the existing evidence concerns myoinositol (MYO), the most abundant form in nature, especially in women with polycystic ovarian syndrome. We have previously shown that MYO increases sperm motility in patients with asthenozoospermia by the increase of sperm mitochondrial membrane potential (MMP), a biofunctional sperm parameter closely associated to sperm motility. The aim of this study was to evaluate the effects of D-chiro-inositol (DCI), another biologically active isoform of inositols, on sperm MMP, as data on this matter has never been released so far. To accomplish this, semen samples from 15 patients with asthenozoospermia and 15 healthy normozoospermic men were incubated with increasing concentrations of DCI (0, 75, and 750 µg/mL) or phosphate buffer saline for 30 min. Incubation with DCI significantly improved sperm MMP at lower concentrations, and with shorter incubation length than those used in our similar MYO studies. In conclusion, these findings indicate that DCI positively impacts on sperm mitochondrial function in vitro. Studies aimed at assessing the role of DCI in the treatment of asthenozoospermia in-vivo are warranted. MDPI 2020-05-07 /pmc/articles/PMC7290519/ /pubmed/32392776 http://dx.doi.org/10.3390/jcm9051373 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Condorelli, Rosita A.
Barbagallo, Federica
Calogero, Aldo E.
Cannarella, Rossella
Crafa, Andrea
La Vignera, Sandro
D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title_full D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title_fullStr D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title_full_unstemmed D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title_short D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence
title_sort d-chiro-inositol improves sperm mitochondrial membrane potential: in vitro evidence
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290519/
https://www.ncbi.nlm.nih.gov/pubmed/32392776
http://dx.doi.org/10.3390/jcm9051373
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