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Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes

Vascular calcification is a major contributor to mortality in end-stage renal disease (ESRD) patients. In this study, we investigated whether there was a correlation between the coronary artery calcium score (CACS) and the vascular calcification score (VCS), and whether higher VCS increased the inci...

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Autores principales: Kim, Hyunsuk, Lee, Bom, Choi, Gwangho, Jin, Ho Yong, Jung, Houn, Hwang, Sunghyun, Yoon, Hojung, Kim, Seok hyung, Park, Hoon Suk, Lee, Jongseok, Yoon, Jong-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290563/
https://www.ncbi.nlm.nih.gov/pubmed/32455765
http://dx.doi.org/10.3390/jcm9051558
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author Kim, Hyunsuk
Lee, Bom
Choi, Gwangho
Jin, Ho Yong
Jung, Houn
Hwang, Sunghyun
Yoon, Hojung
Kim, Seok hyung
Park, Hoon Suk
Lee, Jongseok
Yoon, Jong-Woo
author_facet Kim, Hyunsuk
Lee, Bom
Choi, Gwangho
Jin, Ho Yong
Jung, Houn
Hwang, Sunghyun
Yoon, Hojung
Kim, Seok hyung
Park, Hoon Suk
Lee, Jongseok
Yoon, Jong-Woo
author_sort Kim, Hyunsuk
collection PubMed
description Vascular calcification is a major contributor to mortality in end-stage renal disease (ESRD) patients. In this study, we investigated whether there was a correlation between the coronary artery calcium score (CACS) and the vascular calcification score (VCS), and whether higher VCS increased the incidence of interventions and major adverse cardiac and cerebrovascular events (MACCE). ECG-gated CT, including vascular access and the coronary vessel, was taken. CACS and VCS were calculated by the Agatston method. A comparison of CACS and survival analysis according to VCS groups was performed. Using a cutoff of VCS = 500, 77 patients were divided into two groups. The vintage was significantly older in the higher VCS group. The median CACS was higher in the higher VCS group (21 [0, 171] vs. 552 [93, 2430], p < 0.001). The hazard ratio (HR) for interventions and MACCEs in the higher VCS group increased by 3.2 and 2.3, respectively. Additionally, a longer duration of hemodialysis and higher magnesium levels (>2.5 mg/dL) showed lower HRs for interventions (<1). We quantified VCS and found that it was associated with the CACS. Additionally, higher VCS increased the risk of access interventions and MACCE. VCS of the access site may be suggested as a biomarker to predict ESRD patients.
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spelling pubmed-72905632020-06-17 Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes Kim, Hyunsuk Lee, Bom Choi, Gwangho Jin, Ho Yong Jung, Houn Hwang, Sunghyun Yoon, Hojung Kim, Seok hyung Park, Hoon Suk Lee, Jongseok Yoon, Jong-Woo J Clin Med Article Vascular calcification is a major contributor to mortality in end-stage renal disease (ESRD) patients. In this study, we investigated whether there was a correlation between the coronary artery calcium score (CACS) and the vascular calcification score (VCS), and whether higher VCS increased the incidence of interventions and major adverse cardiac and cerebrovascular events (MACCE). ECG-gated CT, including vascular access and the coronary vessel, was taken. CACS and VCS were calculated by the Agatston method. A comparison of CACS and survival analysis according to VCS groups was performed. Using a cutoff of VCS = 500, 77 patients were divided into two groups. The vintage was significantly older in the higher VCS group. The median CACS was higher in the higher VCS group (21 [0, 171] vs. 552 [93, 2430], p < 0.001). The hazard ratio (HR) for interventions and MACCEs in the higher VCS group increased by 3.2 and 2.3, respectively. Additionally, a longer duration of hemodialysis and higher magnesium levels (>2.5 mg/dL) showed lower HRs for interventions (<1). We quantified VCS and found that it was associated with the CACS. Additionally, higher VCS increased the risk of access interventions and MACCE. VCS of the access site may be suggested as a biomarker to predict ESRD patients. MDPI 2020-05-21 /pmc/articles/PMC7290563/ /pubmed/32455765 http://dx.doi.org/10.3390/jcm9051558 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Hyunsuk
Lee, Bom
Choi, Gwangho
Jin, Ho Yong
Jung, Houn
Hwang, Sunghyun
Yoon, Hojung
Kim, Seok hyung
Park, Hoon Suk
Lee, Jongseok
Yoon, Jong-Woo
Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title_full Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title_fullStr Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title_full_unstemmed Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title_short Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes
title_sort quantified vascular calcification at the dialysis access site: correlations with the coronary artery calcium score and survival analysis of access and cardiovascular outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290563/
https://www.ncbi.nlm.nih.gov/pubmed/32455765
http://dx.doi.org/10.3390/jcm9051558
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