Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome

Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Meth...

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Autores principales: Nishitani-Yokoyama, Miho, Miyauchi, Katsumi, Shimada, Kazunori, Yokoyama, Takayuki, Ouchi, Shohei, Aikawa, Tatsuro, Kunimoto, Mitsuhiro, Yamada, Miki, Honzawa, Akio, Okazaki, Shinya, Tsujita, Hiroaki, Koba, Shinji, Daida, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290587/
https://www.ncbi.nlm.nih.gov/pubmed/32455937
http://dx.doi.org/10.3390/jcm9051578
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author Nishitani-Yokoyama, Miho
Miyauchi, Katsumi
Shimada, Kazunori
Yokoyama, Takayuki
Ouchi, Shohei
Aikawa, Tatsuro
Kunimoto, Mitsuhiro
Yamada, Miki
Honzawa, Akio
Okazaki, Shinya
Tsujita, Hiroaki
Koba, Shinji
Daida, Hiroyuki
author_facet Nishitani-Yokoyama, Miho
Miyauchi, Katsumi
Shimada, Kazunori
Yokoyama, Takayuki
Ouchi, Shohei
Aikawa, Tatsuro
Kunimoto, Mitsuhiro
Yamada, Miki
Honzawa, Akio
Okazaki, Shinya
Tsujita, Hiroaki
Koba, Shinji
Daida, Hiroyuki
author_sort Nishitani-Yokoyama, Miho
collection PubMed
description Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Methods: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA. Results: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level. Conclusions: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS.
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spelling pubmed-72905872020-06-17 Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome Nishitani-Yokoyama, Miho Miyauchi, Katsumi Shimada, Kazunori Yokoyama, Takayuki Ouchi, Shohei Aikawa, Tatsuro Kunimoto, Mitsuhiro Yamada, Miki Honzawa, Akio Okazaki, Shinya Tsujita, Hiroaki Koba, Shinji Daida, Hiroyuki J Clin Med Article Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Methods: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA. Results: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level. Conclusions: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS. MDPI 2020-05-22 /pmc/articles/PMC7290587/ /pubmed/32455937 http://dx.doi.org/10.3390/jcm9051578 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishitani-Yokoyama, Miho
Miyauchi, Katsumi
Shimada, Kazunori
Yokoyama, Takayuki
Ouchi, Shohei
Aikawa, Tatsuro
Kunimoto, Mitsuhiro
Yamada, Miki
Honzawa, Akio
Okazaki, Shinya
Tsujita, Hiroaki
Koba, Shinji
Daida, Hiroyuki
Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title_full Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title_fullStr Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title_full_unstemmed Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title_short Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
title_sort preliminary pilot study of combined effects of physical activity and achievement of ldl-cholesterol target on coronary plaque volume changes in patients with acute coronary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290587/
https://www.ncbi.nlm.nih.gov/pubmed/32455937
http://dx.doi.org/10.3390/jcm9051578
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