The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane

Lipophilic weak base therapeutic agents, termed lysosomotropic drugs (LDs), undergo marked sequestration and concentration within lysosomes, hence altering lysosomal functions. This lysosomal drug entrapment has been described as luminal drug compartmentalization. Consistent with our recent finding...

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Detalles Bibliográficos
Autores principales: Stark, Michal, Silva, Tomás F. D., Levin, Guy, Machuqueiro, Miguel, Assaraf, Yehuda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290590/
https://www.ncbi.nlm.nih.gov/pubmed/32349204
http://dx.doi.org/10.3390/cells9051082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290590/
https://www.ncbi.nlm.nih.gov/pubmed/32349204
http://dx.doi.org/10.3390/cells9051082

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