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Significant Differences in RNA Structure Destabilization by HIV-1 Gag∆p6 and NCp7 Proteins

Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently des...

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Detalles Bibliográficos
Autores principales: McCauley, Micah J., Rouzina, Ioulia, Li, Jasmine, Núñez, Megan E., Williams, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290599/
https://www.ncbi.nlm.nih.gov/pubmed/32344834
http://dx.doi.org/10.3390/v12050484