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The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China

BACKGROUND: A recent cluster of pneumonia cases in Wuhan (China) is known to be caused by a novel beta-coronavirus named the corona virus disease 2019 (COVID-19) and can be spread through human-to-human transmission. METHODS: Data of 21 patients with laboratory-confirmed COVID-19 and 84 patients wit...

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Autores principales: Xie, Shuanshuan, Zhang, Guoliang, Yu, Hong, Wang, Jin, Wang, Sheng, Tang, Guangyu, Guo, Changfeng, Li, Jiyu, Wei, Songhua, Wang, Changhui, Qin, Huanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290637/
https://www.ncbi.nlm.nih.gov/pubmed/32566574
http://dx.doi.org/10.21037/atm-20-2119
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author Xie, Shuanshuan
Zhang, Guoliang
Yu, Hong
Wang, Jin
Wang, Sheng
Tang, Guangyu
Guo, Changfeng
Li, Jiyu
Wei, Songhua
Wang, Changhui
Qin, Huanlong
author_facet Xie, Shuanshuan
Zhang, Guoliang
Yu, Hong
Wang, Jin
Wang, Sheng
Tang, Guangyu
Guo, Changfeng
Li, Jiyu
Wei, Songhua
Wang, Changhui
Qin, Huanlong
author_sort Xie, Shuanshuan
collection PubMed
description BACKGROUND: A recent cluster of pneumonia cases in Wuhan (China) is known to be caused by a novel beta-coronavirus named the corona virus disease 2019 (COVID-19) and can be spread through human-to-human transmission. METHODS: Data of 21 patients with laboratory-confirmed COVID-19 and 84 patients with suspected COVID-19 were analyzed by RT-PCR. The epidemiologic and clinical features as well as clinical outcomes were compared between the confirmed and suspected cases. RESULTS: Altogether 105 patients had been enrolled in this study by February 15, 2020 in north Shanghai, including 21 confirmed cases and 84 suspected cases of COVID-19. The incubation period of these confirmed patients with imported COVID-19 was 17.6 days (IQR 5–34 days) and the median time from symptom onset to diagnosis was 145.64 h (IQR 21–441 h). More than 50% of the confirmed patients were older than 51 (range, 51–60) years. Fifty (59.5%) of the 84 probably patients were younger than 40 years, including 27 (32%) patients younger than 30 years. Most confirmed patients were men (61.9%, 13/21), and less than 50% of them had underlying diseases, including diabetes (9.5%, 2/21), hypertension (19%, 4/21), COPD (23.8%, 5/21), and CD (23.8%, 5/21). In addition, 10 (47.6%) of the 21 confirmed patients were ordinary employees, and 12 (57.2%) of them had recently been to Wuhan or had close contacts with people from Wuhan. Of the 84 suspected patients, 28 (33.3%) were retired employees; 69 (82.1%) had recently been to supermarkets and groceries or had a history of traveling abroad or to other cities of China. The common onset symptoms of the patients in both groups were fever and cough. The symptom of Sputum production was more pronounced in probably patients (40.5%, 34/84) than that in confirmed patients (9.5%, 2/21). More than 50% imported patients (53.3%, 56/105) had one and two affected lobes. Twenty-nine (27.6%) of the 105 imported patients had been discharged, no patient had died, and all the other patients are still in hospital. CONCLUSIONS: The overall incubation period in this cohort of imported confirmed COVID-19 patients was longer than that in Wuhan, mostly infecting older men. The disease onset of imported COVID-19 infection was occult, and the clinical symptoms were usually mild, mostly presenting as low fever, fatigue, light cough, and mild dyspnea.
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spelling pubmed-72906372020-06-19 The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China Xie, Shuanshuan Zhang, Guoliang Yu, Hong Wang, Jin Wang, Sheng Tang, Guangyu Guo, Changfeng Li, Jiyu Wei, Songhua Wang, Changhui Qin, Huanlong Ann Transl Med Original Article BACKGROUND: A recent cluster of pneumonia cases in Wuhan (China) is known to be caused by a novel beta-coronavirus named the corona virus disease 2019 (COVID-19) and can be spread through human-to-human transmission. METHODS: Data of 21 patients with laboratory-confirmed COVID-19 and 84 patients with suspected COVID-19 were analyzed by RT-PCR. The epidemiologic and clinical features as well as clinical outcomes were compared between the confirmed and suspected cases. RESULTS: Altogether 105 patients had been enrolled in this study by February 15, 2020 in north Shanghai, including 21 confirmed cases and 84 suspected cases of COVID-19. The incubation period of these confirmed patients with imported COVID-19 was 17.6 days (IQR 5–34 days) and the median time from symptom onset to diagnosis was 145.64 h (IQR 21–441 h). More than 50% of the confirmed patients were older than 51 (range, 51–60) years. Fifty (59.5%) of the 84 probably patients were younger than 40 years, including 27 (32%) patients younger than 30 years. Most confirmed patients were men (61.9%, 13/21), and less than 50% of them had underlying diseases, including diabetes (9.5%, 2/21), hypertension (19%, 4/21), COPD (23.8%, 5/21), and CD (23.8%, 5/21). In addition, 10 (47.6%) of the 21 confirmed patients were ordinary employees, and 12 (57.2%) of them had recently been to Wuhan or had close contacts with people from Wuhan. Of the 84 suspected patients, 28 (33.3%) were retired employees; 69 (82.1%) had recently been to supermarkets and groceries or had a history of traveling abroad or to other cities of China. The common onset symptoms of the patients in both groups were fever and cough. The symptom of Sputum production was more pronounced in probably patients (40.5%, 34/84) than that in confirmed patients (9.5%, 2/21). More than 50% imported patients (53.3%, 56/105) had one and two affected lobes. Twenty-nine (27.6%) of the 105 imported patients had been discharged, no patient had died, and all the other patients are still in hospital. CONCLUSIONS: The overall incubation period in this cohort of imported confirmed COVID-19 patients was longer than that in Wuhan, mostly infecting older men. The disease onset of imported COVID-19 infection was occult, and the clinical symptoms were usually mild, mostly presenting as low fever, fatigue, light cough, and mild dyspnea. AME Publishing Company 2020-05 /pmc/articles/PMC7290637/ /pubmed/32566574 http://dx.doi.org/10.21037/atm-20-2119 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Xie, Shuanshuan
Zhang, Guoliang
Yu, Hong
Wang, Jin
Wang, Sheng
Tang, Guangyu
Guo, Changfeng
Li, Jiyu
Wei, Songhua
Wang, Changhui
Qin, Huanlong
The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title_full The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title_fullStr The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title_full_unstemmed The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title_short The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China
title_sort epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north shanghai, china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290637/
https://www.ncbi.nlm.nih.gov/pubmed/32566574
http://dx.doi.org/10.21037/atm-20-2119
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