Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, includ...

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Detalles Bibliográficos
Autores principales: Nashine, Sonali, Kenney, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290668/
https://www.ncbi.nlm.nih.gov/pubmed/32365540
http://dx.doi.org/10.3390/cells9051102
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author Nashine, Sonali
Kenney, M. Cristina
author_facet Nashine, Sonali
Kenney, M. Cristina
author_sort Nashine, Sonali
collection PubMed
description Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.
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spelling pubmed-72906682020-06-17 Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD Nashine, Sonali Kenney, M. Cristina Cells Review Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy. MDPI 2020-04-29 /pmc/articles/PMC7290668/ /pubmed/32365540 http://dx.doi.org/10.3390/cells9051102 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nashine, Sonali
Kenney, M. Cristina
Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_full Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_fullStr Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_full_unstemmed Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_short Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_sort effects of mitochondrial-derived peptides (mdps) on mitochondrial and cellular health in amd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290668/
https://www.ncbi.nlm.nih.gov/pubmed/32365540
http://dx.doi.org/10.3390/cells9051102
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