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Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants

Phosphatidylinositol 3-kinase, catalytic subunit alpha (PIK3CA) is an oncogene often mutated in colorectal cancer (CRC). The contribution of PIK3CA mutations in acquired resistance to anti-epidermal growth factor receptor (EGFR) therapy is well documented, but their prognostic and predictive value r...

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Detalles Bibliográficos
Autores principales:	Ghodsinia, Arman Ali, Lego, J-Ann Marie T., Garcia, Reynaldo L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290687/ https://www.ncbi.nlm.nih.gov/pubmed/32365913 http://dx.doi.org/10.3390/cells9051116

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