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NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up

The CYBA gene encodes the regulatory subunit of NADPH oxidase, which maintains the redox state within cells and in the blood vessels. That led us to investigate the course of coronary artery disease (CAD) with regards to CYBA polymorphisms. Thus, we recruited 1197 subjects with coronary atherosclero...

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Autores principales: Racis, Milena, Sobiczewski, Wojciech, Stanisławska-Sachadyn, Anna, Wirtwein, Marcin, Bluj, Elżbieta, Nedoszytko, Michał, Borzyszkowska, Joanna, Limon, Janusz, Rynkiewicz, Andrzej, Gruchała, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290726/
https://www.ncbi.nlm.nih.gov/pubmed/32423015
http://dx.doi.org/10.3390/jcm9051475
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author Racis, Milena
Sobiczewski, Wojciech
Stanisławska-Sachadyn, Anna
Wirtwein, Marcin
Bluj, Elżbieta
Nedoszytko, Michał
Borzyszkowska, Joanna
Limon, Janusz
Rynkiewicz, Andrzej
Gruchała, Marcin
author_facet Racis, Milena
Sobiczewski, Wojciech
Stanisławska-Sachadyn, Anna
Wirtwein, Marcin
Bluj, Elżbieta
Nedoszytko, Michał
Borzyszkowska, Joanna
Limon, Janusz
Rynkiewicz, Andrzej
Gruchała, Marcin
author_sort Racis, Milena
collection PubMed
description The CYBA gene encodes the regulatory subunit of NADPH oxidase, which maintains the redox state within cells and in the blood vessels. That led us to investigate the course of coronary artery disease (CAD) with regards to CYBA polymorphisms. Thus, we recruited 1197 subjects with coronary atherosclerosis and observed them during 7-year follow-up. Three CYBA polymorphisms: c.214C>T (rs4673), c.-932G>A (rs9932581), and c.*24G>A (1049255) were studied for an association with death, major adverse cardiovascular events (MACE) and an elective percutaneous coronary intervention or coronary artery bypass grafting (PCI/CABG). We found an association between the CYBA c.214C>T polymorphism and two end points: death and PCI/CABG. CYBA c.214TT genotype was associated with a lower risk of death than C allele (9.5% vs. 21%, p < 0.05) and a higher risk of PCI/CABG than C allele (69.3% vs. 51.7%, p < 0.01). This suggests that the CYBA c.214TT genotype may be a protective factor against death OR = 0.47 (95%CI 0.28–0.82; p < 0.01), while also being a risk factor for an elective PCI/CABG OR = 2.36 (95%CI 1.15–4.82; p < 0.05). Thus, we hypothesize that among patients with coronary atherosclerosis, the CYBA c.214TT genotype contributes to atherosclerotic plaque stability by altering the course of CAD towards chronic coronary syndrome, thereby lowering the incidence of fatal CAD-related events.
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spelling pubmed-72907262020-06-17 NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up Racis, Milena Sobiczewski, Wojciech Stanisławska-Sachadyn, Anna Wirtwein, Marcin Bluj, Elżbieta Nedoszytko, Michał Borzyszkowska, Joanna Limon, Janusz Rynkiewicz, Andrzej Gruchała, Marcin J Clin Med Article The CYBA gene encodes the regulatory subunit of NADPH oxidase, which maintains the redox state within cells and in the blood vessels. That led us to investigate the course of coronary artery disease (CAD) with regards to CYBA polymorphisms. Thus, we recruited 1197 subjects with coronary atherosclerosis and observed them during 7-year follow-up. Three CYBA polymorphisms: c.214C>T (rs4673), c.-932G>A (rs9932581), and c.*24G>A (1049255) were studied for an association with death, major adverse cardiovascular events (MACE) and an elective percutaneous coronary intervention or coronary artery bypass grafting (PCI/CABG). We found an association between the CYBA c.214C>T polymorphism and two end points: death and PCI/CABG. CYBA c.214TT genotype was associated with a lower risk of death than C allele (9.5% vs. 21%, p < 0.05) and a higher risk of PCI/CABG than C allele (69.3% vs. 51.7%, p < 0.01). This suggests that the CYBA c.214TT genotype may be a protective factor against death OR = 0.47 (95%CI 0.28–0.82; p < 0.01), while also being a risk factor for an elective PCI/CABG OR = 2.36 (95%CI 1.15–4.82; p < 0.05). Thus, we hypothesize that among patients with coronary atherosclerosis, the CYBA c.214TT genotype contributes to atherosclerotic plaque stability by altering the course of CAD towards chronic coronary syndrome, thereby lowering the incidence of fatal CAD-related events. MDPI 2020-05-14 /pmc/articles/PMC7290726/ /pubmed/32423015 http://dx.doi.org/10.3390/jcm9051475 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Racis, Milena
Sobiczewski, Wojciech
Stanisławska-Sachadyn, Anna
Wirtwein, Marcin
Bluj, Elżbieta
Nedoszytko, Michał
Borzyszkowska, Joanna
Limon, Janusz
Rynkiewicz, Andrzej
Gruchała, Marcin
NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title_full NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title_fullStr NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title_full_unstemmed NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title_short NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up
title_sort nadph oxidase gene polymorphism is associated with mortality and cardiovascular events in 7-year follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290726/
https://www.ncbi.nlm.nih.gov/pubmed/32423015
http://dx.doi.org/10.3390/jcm9051475
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