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Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo

Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antivir...

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Autores principales: Zhang, Li, Chen, Jungang, Ke, Chang, Zhang, Haiwei, Zhang, Shoujun, Tang, Wei, Liu, Chunlan, Liu, Ge, Chen, Si, Hu, Ao, Sun, Wenyu, Xiao, Yu, Liu, Minli, Chen, Xulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290740/
https://www.ncbi.nlm.nih.gov/pubmed/32443510
http://dx.doi.org/10.3390/v12050557
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author Zhang, Li
Chen, Jungang
Ke, Chang
Zhang, Haiwei
Zhang, Shoujun
Tang, Wei
Liu, Chunlan
Liu, Ge
Chen, Si
Hu, Ao
Sun, Wenyu
Xiao, Yu
Liu, Minli
Chen, Xulin
author_facet Zhang, Li
Chen, Jungang
Ke, Chang
Zhang, Haiwei
Zhang, Shoujun
Tang, Wei
Liu, Chunlan
Liu, Ge
Chen, Si
Hu, Ao
Sun, Wenyu
Xiao, Yu
Liu, Minli
Chen, Xulin
author_sort Zhang, Li
collection PubMed
description Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there have been no effective drugs as yet to cure all patients infected by influenza viruses. Natural products from plants contain compounds with diverse structures that have the potential to interact with multiple host and virus factors. In this study, we identified the ethanol extract of Caesalpinia decapetala (Roth) Alston (EEC) as an inhibitor against the replication of a panel of influenza A and B viruses both on human pulmonary epithelial A549 and human monocytic U937 cells. The animal study revealed that EEC administration reduces the weight loss and improves the survival rate of mice infected with lethal influenza virus. Also, EEC treatment attenuated lung injury and reduced virus titer significantly. In conclusion, we showed that EEC has antiviral activity both in vitro and in vivo, suggesting that the plant C. decapetala has the potential to be further developed as a resource of new anti-influenza drugs.
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spelling pubmed-72907402020-06-17 Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo Zhang, Li Chen, Jungang Ke, Chang Zhang, Haiwei Zhang, Shoujun Tang, Wei Liu, Chunlan Liu, Ge Chen, Si Hu, Ao Sun, Wenyu Xiao, Yu Liu, Minli Chen, Xulin Viruses Article Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there have been no effective drugs as yet to cure all patients infected by influenza viruses. Natural products from plants contain compounds with diverse structures that have the potential to interact with multiple host and virus factors. In this study, we identified the ethanol extract of Caesalpinia decapetala (Roth) Alston (EEC) as an inhibitor against the replication of a panel of influenza A and B viruses both on human pulmonary epithelial A549 and human monocytic U937 cells. The animal study revealed that EEC administration reduces the weight loss and improves the survival rate of mice infected with lethal influenza virus. Also, EEC treatment attenuated lung injury and reduced virus titer significantly. In conclusion, we showed that EEC has antiviral activity both in vitro and in vivo, suggesting that the plant C. decapetala has the potential to be further developed as a resource of new anti-influenza drugs. MDPI 2020-05-18 /pmc/articles/PMC7290740/ /pubmed/32443510 http://dx.doi.org/10.3390/v12050557 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Li
Chen, Jungang
Ke, Chang
Zhang, Haiwei
Zhang, Shoujun
Tang, Wei
Liu, Chunlan
Liu, Ge
Chen, Si
Hu, Ao
Sun, Wenyu
Xiao, Yu
Liu, Minli
Chen, Xulin
Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title_full Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title_fullStr Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title_full_unstemmed Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title_short Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
title_sort ethanol extract of caesalpinia decapetala inhibits influenza virus infection in vitro and in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290740/
https://www.ncbi.nlm.nih.gov/pubmed/32443510
http://dx.doi.org/10.3390/v12050557
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