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EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats

Sirtuin (SIRT) is known to prevent nonalcoholic fatty liver disease (NAFLD); however, the role of SIRT4 in the progression of hepatic fibrosis remains unknown. We hypothesize that EX-527, a selective SIRT1 inhibitor, can inhibit the progression of high-fat diet (HFD)-induced hepatic fibrosis. We fou...

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Detalles Bibliográficos
Autores principales:	Kundu, Amit, Dey, Prasanta, Park, Jae Hyeon, Kim, In Su, Kwack, Seung Jun, Kim, Hyung Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290750/ https://www.ncbi.nlm.nih.gov/pubmed/32365537 http://dx.doi.org/10.3390/cells9051101

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