Cargando…

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats

Sirtuin (SIRT) is known to prevent nonalcoholic fatty liver disease (NAFLD); however, the role of SIRT4 in the progression of hepatic fibrosis remains unknown. We hypothesize that EX-527, a selective SIRT1 inhibitor, can inhibit the progression of high-fat diet (HFD)-induced hepatic fibrosis. We fou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kundu, Amit, Dey, Prasanta, Park, Jae Hyeon, Kim, In Su, Kwack, Seung Jun, Kim, Hyung Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290750/ https://www.ncbi.nlm.nih.gov/pubmed/32365537 http://dx.doi.org/10.3390/cells9051101

Ejemplares similares

Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)
por: Broussy, Sylvain, et al.
Publicado: (2020)

Dietary walnut oil modulates liver steatosis in the obese Zucker rat
por: Fink, Anja, et al.
Publicado: (2013)

Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
por: Kim, Junghyun, et al.
Publicado: (2013)

Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells
por: Dey, Prasanta, et al.
Publicado: (2020)

Don Giovanni KV 527
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1992)

Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways
por: Kundu, Amit, et al.
Publicado: (2022)

Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1
por: Shatoor, Abdullah S., et al.
Publicado: (2021)

Lipopolysaccharides accelerate hepatic steatosis in the development of nonalcoholic fatty liver disease in Zucker rats
por: Fukunishi, Shinya, et al.
Publicado: (2014)

Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
por: Sachan, Richa, et al.
Publicado: (2020)

Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
por: Kim, Kyung Eun, et al.
Publicado: (2015)

The association of hepatic steatosis and fibrosis with heart failure and mortality
por: Park, Jiyun, et al.
Publicado: (2021)

Pancreatic Fat Accumulation, Fibrosis, and Acinar Cell Injury in the Zucker Diabetic Fatty Rat Fed a Chronic High-Fat Diet
por: Matsuda, Akiko, et al.
Publicado: (2014)

Development of Fibrosis in Nonalcoholic Steatosis through Combination of a Synthetic Diet Rich in Disaccharide and Low-Dose Lipopolysaccharides in the Livers of Zucker (fa/fa) Rats
por: Fukunishi, Shinya, et al.
Publicado: (2009)

Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway
por: Jia, Jie, et al.
Publicado: (2023)

Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model
por: Robeson, Michael S., et al.
Publicado: (2022)

Carvacrol Protects against Hepatic Steatosis in Mice Fed a High-Fat Diet by Enhancing SIRT1-AMPK Signaling
por: Kim, Eunkyung, et al.
Publicado: (2013)

A Korean Patient with Lattice Corneal Dystrophy Type IV with Leu527Arg Mutation in the TGFBI Gene
por: Kim, Jinsun, et al.
Publicado: (2014)

Anti-Obesity Effects of Artemisia annua Extract in Zucker Fatty Rats and High-Fat Diet Sprague Dawley Rats through Upregulation of Uncoupling Protein 1
por: Choi, Eun-Yong, et al.
Publicado: (2021)

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
por: Dey, Prasanta, et al.
Publicado: (2020)

Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats
por: Tan, Yi, et al.
Publicado: (2017)

Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways
por: Dey, Prasanta, et al.
Publicado: (2022)

Pepsin Egg White Hydrolysate Ameliorates Obesity-Related Oxidative Stress, Inflammation and Steatosis in Zucker Fatty Rats
por: Garcés-Rimón, M., et al.
Publicado: (2016)

Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats
por: Ogura, Yoshio, et al.
Publicado: (2018)

Deletion of adipocyte prohibitin 1 exacerbates high‐fat diet‐induced steatosis but not liver inflammation and fibrosis
por: Wang, Xiaolin, et al.
Publicado: (2022)

Upregulation of adiponectin by Ginsenoside Rb1 contributes to amelioration of hepatic steatosis induced by high fat diet
por: Li, Yaru, et al.
Publicado: (2022)

Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats
por: Kozaczek, Melisa, et al.
Publicado: (2020)

Novel SIRT1 inhibitor 15-deoxy-Δ(12,14)-prostaglandin J(2) and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells
por: Tae, In Hwan, et al.
Publicado: (2018)

Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives
por: Dey, Prasanta, et al.
Publicado: (2019)

527 Evaluation of the September Epidemic of Asthma Exacerbation in Children in Our Practice
por: Nemeth II, Agnes
Publicado: (2012)

Association between microRNA-527 and glypican-3 in hepatocellular carcinoma
por: Nomura, Kei, et al.
Publicado: (2021)

Nucleoside analogs NM107 and AT-527 are antiviral against rubella virus
por: Dittmar, Mark, et al.
Publicado: (2023)

Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma
por: Dey, Prasanta, et al.
Publicado: (2019)

Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway
por: Na, Ann-Yae, et al.
Publicado: (2018)

Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats
por: Chohnan, Shigeru, et al.
Publicado: (2020)

Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
por: Jia, Li, et al.
Publicado: (2016)

Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver
por: Yoo, Ahyoung, et al.
Publicado: (2017)

KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats
por: Kim, Junghyun, et al.
Publicado: (2011)

Hepatic Fibrosis and Steatosis in Metabolic Syndrome
por: Gangireddy, Venu Gopala Reddy, et al.
Publicado: (2022)

KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
por: Kim, Young Sook, et al.
Publicado: (2011)

Effects of habitual exercise and dietary restriction on intrahepatic and periepididymal fat accumulation in Zucker fatty rats
por: Kurosaka, Yuka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_r23npjcq1jgrt85q1qsmpofii3