The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tg(fb)) that is restricted to the fo...

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Detalles Bibliográficos
Autores principales: Zoicas, Iulia, Schumacher, Fabian, Kleuser, Burkhard, Reichel, Martin, Gulbins, Erich, Fejtova, Anna, Kornhuber, Johannes, Rhein, Cosima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290754/
https://www.ncbi.nlm.nih.gov/pubmed/32443534
http://dx.doi.org/10.3390/cells9051244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290754/
https://www.ncbi.nlm.nih.gov/pubmed/32443534
http://dx.doi.org/10.3390/cells9051244

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