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The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tg(fb)) that is restricted to the fo...

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Detalles Bibliográficos
Autores principales:	Zoicas, Iulia, Schumacher, Fabian, Kleuser, Burkhard, Reichel, Martin, Gulbins, Erich, Fejtova, Anna, Kornhuber, Johannes, Rhein, Cosima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290754/ https://www.ncbi.nlm.nih.gov/pubmed/32443534 http://dx.doi.org/10.3390/cells9051244

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